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Copyright: © Martin Braun Fotografie

Person

Univ.Prof.Dr.med.

Fabian Kießling

Helmholtz Institute for Biomedical Engineering

Head of Institute

Address

Building: CBMS

Room: 102

Forckenbeckstraße 55

52074 Aachen

Contact

WorkPhone

Phone: +49 241 80 80116

Fax Fax: +49 241 80 33 80116

Email: fkiessling@ukaachen.de

Website

Since 2008 Professor Dr. Fabian Kiessling is leading the Institute of Experimental Molecular Imaging.

Aim of his research is the development of novel diagnostic probes and imaging tools for a disease specific diagnosis and therapy monitoring. He authored over 400 publications and book chapters, edited four books, and received multiple research awards and honours among those the „Emil Salzer Prize for Cancer Research” and the “Richtzenhain Prize”. In 2019 and 2020 he has been on the list of Clarivate’s Highly Cited Researchers (Web of Science).

Fabian Kiessling studied Medicine and did his thesis at the University in Heidelberg. Until the end of 2002, he worked as resident in the Department of Radiology at the German Cancer Research Center (DKFZ) in Heidelberg. In 2003 he changed to the Department of Medical Physics in Radiology of the DKFZ as leader of the Molecular Imaging group. In parallel he did his clinical training at different Departments of the University of Heidelberg and received the board certification as Radiologist in 2007. Fabian Kiessling did his habilitation in experimental radiology in 2006. In 2008 he founded the invivoContrast GmbH together with Matthias Braeutigam.

Professor Kiessling has served in the Editorial board of several scientific journals including Radiology, European Radiology, J Nuclear Medicine, and Molecular Imaging and Biology.

He was founding member of the European Society for Functional and Molecular Imaging in Radiology (ESMOFIR), for many years has been active in the executive council of the European Society for Molecular Imaging (ESMI) as treasurer and secretary. In addition, in 2014 he chaired the “Molecular Imaging” subcommittee of the European Society for Radiology (ESR) and was appointed as program chair of the World Molecular Imaging Conference (WMIS) in New York in 2016. In 2020 he was awarded by the World Molecular Imaging Society as Fellow.

Fabian Kiessling served for many years on the board of the European Society for Molecular Imaging (ESMI) as treasurer and secretary.

Selected Publications

1. Hage C.*, Hoves S., Strauss L., Bissinger S., Prinz Y., Pöschinger T., Kiessling F.*, Ries C.H. Sorafenib induces pyroptosis in macrophages and triggers NK cell-mediated cytotoxicity against hepatocellular carcinoma. Hepatology, 2019, 70:1280-1297 (* corresponding authors)

2. Opacic T., Dencks S., Theek B., Piepenbrock M., Ackermann D., Rix A., Lammers T., Stickeler E., Delorme S., Schmitz G., Kiessling F. Motion Model Ultrasound Localization Microscopy for Preclinical and Clinical Multiparametric Tumor Characterization. Nat Commun, 2018, 9:1527

3. Tsvetkova Y., Beztsinna N., Baues M., Klein D., Rix A., Golombek S., Al Rawashdeh W., Gremse F., Barz M., Koynov K., Banala S., Lederle W., Lammers T., Kiessling F. Balancing Passive and Active Targeting to Different Tumor Compartments Using Riboflavin-functionalized Polymeric Nanocarriers. Nano Lett, 2017, 17:4665‑4674

4. Lammers T., Koczera P., Fokong S., Gremse F., Ehling J., Vogt M., Pich A., Storm G., van Zandvoort M., Kiessling F. Theranostic USPIO-loaded microbubbles for mediating and monitoring blood-brain barrier permeation. Adv Funct Mater, 2015, 25:36-43

5. Mertens M.E., Koch S., Schuster P., Wehner J., Wu Z., Gremse F., Schulz V., Rongen L., Wolf F., Frese J., Gesché V.N., van Zandvoort M., Mela P., Jockenhoevel S.*, Kiessling F.*, Lammers T*. USPIO-labeled textile materials for non-invasive MR imaging of tissue-engineered vascular grafts. Biomaterials, 2015, 39:155-163 (*corresponding authors)

6. Gremse F., Theek B., Kunjachan S., Lederle W., Pardo A., Barth S., Lammers T., Naumann U., Kiessling F. Absorption reconstruction improves biodistribution assessment of fluorescent nanoprobes using hybrid fluorescence-mediated tomography. Theranostics, 2014, 4:960-71

7. Palmowski M., Huppert J., Hauff P., Reinhardt M., Schreiner K., Socher M.A., Hallscheidt P., Kauffmann G.W., Semmler W., Kiessling F. Vessel fractions in tumor xenografts depicted by flow- or contrast-sensitive 3D high-frequency Doppler Ultrasound respond differently to multispecific tyrosine kinase receptor inhibition. Cancer Res, 2008, 68:7042-7049

8. Palmowski M., Huppert J., Ladewig G., Hauff P., Reinhardt M., Mueller M.M., Woenne E.C., Jenne J.W., Maurer M., Kauffmann G.W., Semmler W., Kiessling F. Molecular profiling of angiogenesis with targeted ultrasound imaging: early assessment of anti-angiogenic therapy effects. Mol Cancer Ther,2008, 7:101-09

9. Zhang C., Jugold M., Woenne E.C., Lammers T., Morgenstern B., Mueller M.M., Zentgraf H., Bock M., Eisenhut M., Semmler W., Kiessling F. Specific targeting of tumor angiogenesis by RGD-conjugated USPIO using a clinical 1.5 T MR-scanner. Cancer Res, 2007, 67:1555-1562

10. Kiessling F., Greschus S., Lichy M.P., Bock M., Fink C., Vosseler S., Moll J., Mueller M.M., Fusenig N.E., Traupe H., Semmler W. Volumetric Computed Tomography (VCT): A novel technology for non-invasive high resolution monitoring of tumor angiogenesis. Nature Med, 2004, 10:1133-1138

Publications