Person

Dr. med., Universitätsprofessor

Fabian Kießling

Head of Institute

Fabian Kießling Copyright: © Martin Braun Fotografie
Lehrstuhl für Experimentelle Molekulare Bildgebung

Address

Building: CBMS

Room: 102

Forckenbeckstr. 55

52074 Aachen

Contact

WorkPhone
Phone: +49 241 80 80117
 

Since 2008 Professor Dr. Fabian Kiessling is leading the Institute of Experimental Molecular Imaging.

Aim of his research is the development of novel diagnostic probes and imaging tools for a disease specific diagnosis and therapy monitoring. He authored over 400 publications and book chapters, edited four books, and received multiple research awards and honours among those the „Emil Salzer Prize for Cancer Research” and the “Richtzenhain Prize”. In 2019 and 2020 he has been on the list of Clarivate’s Highly Cited Researchers (Web of Science).

Fabian Kiessling studied Medicine and did his thesis at the University in Heidelberg. Until the end of 2002, he worked as resident in the Department of Radiology at the German Cancer Research Center (DKFZ) in Heidelberg. In 2003 he changed to the Department of Medical Physics in Radiology of the DKFZ as leader of the Molecular Imaging group. In parallel he did his clinical training at different Departments of the University of Heidelberg and received the board certification as Radiologist in 2007. Fabian Kiessling did his habilitation in experimental radiology in 2006. In 2008 he founded the invivoContrast GmbH together with Matthias Braeutigam.

Professor Kiessling has served in the Editorial board of several scientific journals including Radiology, European Radiology, J Nuclear Medicine, and Molecular Imaging and Biology.

He was founding member of the European Society for Functional and Molecular Imaging in Radiology (ESMOFIR), for many years has been active in the executive council of the European Society for Molecular Imaging (ESMI) as treasurer and secretary. In addition, in 2014 he chaired the “Molecular Imaging” subcommittee of the European Society for Radiology (ESR) and was appointed as program chair of the World Molecular Imaging Conference (WMIS) in New York in 2016. In 2020 he was awarded by the World Molecular Imaging Society as Fellow.

Fabian Kiessling served for many years on the board of the European Society for Molecular Imaging (ESMI) as treasurer and secretary.

Selected Publications

  1. Hage C.*, Hoves S., Strauss L., Bissinger S., Prinz Y., Pöschinger T., Kiessling F.*, Ries C.H. Sorafenib induces pyroptosis in macrophages and triggers NK cell-mediated cytotoxicity against hepatocellular carcinoma. Hepatology, 2019, 70:1280-1297 (* corresponding authors)

  2. Opacic T., Dencks S., Theek B., Piepenbrock M., Ackermann D., Rix A., Lammers T., Stickeler E., Delorme S., Schmitz G., Kiessling F. Motion Model Ultrasound Localization Microscopy for Preclinical and Clinical Multiparametric Tumor Characterization. Nat Commun, 2018, 9:1527

  3. Tsvetkova Y., Beztsinna N., Baues M., Klein D., Rix A., Golombek S., Al Rawashdeh W., Gremse F., Barz M., Koynov K., Banala S., Lederle W., Lammers T., Kiessling F. Balancing Passive and Active Targeting to Different Tumor Compartments Using Riboflavin-functionalized Polymeric Nanocarriers. Nano Lett, 2017, 17:4665‑4674

  4. Lammers T., Koczera P., Fokong S., Gremse F., Ehling J., Vogt M., Pich A., Storm G., van Zandvoort M., Kiessling F. Theranostic USPIO-loaded microbubbles for mediating and monitoring blood-brain barrier permeation. Adv Funct Mater, 2015, 25:36-43

  5. Mertens M.E., Koch S., Schuster P., Wehner J., Wu Z., Gremse F., Schulz V., Rongen L., Wolf F., Frese J., Gesché V.N., van Zandvoort M., Mela P., Jockenhoevel S.*, Kiessling F.*, Lammers T*. USPIO-labeled textile materials for non-invasive MR imaging of tissue-engineered vascular grafts. Biomaterials, 2015, 39:155-163 (*corresponding authors)

  6. Gremse F., Theek B., Kunjachan S., Lederle W., Pardo A., Barth S., Lammers T., Naumann U., Kiessling F. Absorption reconstruction improves biodistribution assessment of fluorescent nanoprobes using hybrid fluorescence-mediated tomography. Theranostics, 2014, 4:960-71

  7. Palmowski M., Huppert J., Hauff P., Reinhardt M., Schreiner K., Socher M.A., Hallscheidt P., Kauffmann G.W., Semmler W., Kiessling F. Vessel fractions in tumor xenografts depicted by flow- or contrast-sensitive 3D high-frequency Doppler Ultrasound respond differently to multispecific tyrosine kinase receptor inhibition. Cancer Res, 2008, 68:7042-7049

  8. Palmowski M., Huppert J., Ladewig G., Hauff P., Reinhardt M., Mueller M.M., Woenne E.C., Jenne J.W., Maurer M., Kauffmann G.W., Semmler W., Kiessling F. Molecular profiling of angiogenesis with targeted ultrasound imaging: early assessment of anti-angiogenic therapy effects. Mol Cancer Ther,2008, 7:101-09

  9. Zhang C., Jugold M., Woenne E.C., Lammers T., Morgenstern B., Mueller M.M., Zentgraf H., Bock M., Eisenhut M., Semmler W., Kiessling F. Specific targeting of tumor angiogenesis by RGD-conjugated USPIO using a clinical 1.5 T MR-scanner. Cancer Res, 2007, 67:1555-1562

  10. Kiessling F., Greschus S., Lichy M.P., Bock M., Fink C., Vosseler S., Moll J., Mueller M.M., Fusenig N.E., Traupe H., Semmler W. Volumetric Computed Tomography (VCT): A novel technology for non-invasive high resolution monitoring of tumor angiogenesis. Nature Med, 2004, 10:1133-1138

 

Publications

Title Author(s)
[Journal Article]
Characterization and molecular imaging of a biohybrid tissue engineered vascular graft
In: Biomedical engineering, 66 (s1), 28 - 28, 2021
[DOI: 10.1515/bmt-2021-6005]
Mohapatra, Saurav Ranjan (Corresponding author)
Rama, Elena
Melcher, Christoph
Apel, Christian
Kiessling, Fabian
Jockenhövel, Stefan
[Journal Article]
Aktivierung der katalytischen Aktivität von Thrombin für die Bildung von Fibrin durch Ultraschall
In: Angewandte Chemie, 133 (26), 14829-14836, 2021
[DOI: 10.1002/ange.202105404]
Zhao, Pengkun
Huo, Shuaidong
Fan, Jilin
Chen, Junlin
Kiessling, Fabian
Boersma, Arnold J.
Göstl, Robert
Herrmann, Andreas (Corresponding author)
[Journal Article]
Activation of the Catalytic Activity of Thrombin for Fibrin Formation by Ultrasound
In: Angewandte Chemie / International edition, 60 (26), 14707-14714, 2021
[DOI: 10.1002/anie.202105404]
Zhao, Pengkun
Huo, Shuaidong (Corresponding author)
Fan, Jilin
Chen, Junlin
Kiessling, Fabian
Boersma, Arnold J.
Göstl, Robert
Herrmann, Andreas (Corresponding author)
[Journal Article]
? electron-stabilized polymeric micelles potentiate docetaxel therapy in advanced-stage gastrointestinal cancer
In: Biomaterials: biomaterials reviews online, 266, 120432, 2021
[DOI: 10.1016/j.biomaterials.2020.120432]
Liang, Chenghua
Bai, Xiangyang
Qi, Cuiling
Sun, Qingxue
Han, Xiaoyan
Lan, Tianyun
Zhang, Haibo
Zheng, Xiaoming
Liang, Rongpu
Jiao, Ju
Zheng, Zongheng
Fang, Jiafeng
Lei, Purun
Wang, Yan
Möckel, Diana
Metselaar, Josbert M.
Storm, Gert
Hennink, Wim E.
Kiessling, Fabian
Wei, Hongbo
Lammers, Twan
Shi, Yang
Wei, Bo
[Journal Article]
US Microbubbles as Smart Sensors of Portal Venous Pressure
In: Radiology, 298 (1), 112-113, 2021
[DOI: 10.1148/radiol.2020203753]
Kiessling, Fabian
[Journal Article]
Roadmap on nanomedicine
In: Nanotechnology, 32 (1), 012001, 2021
[DOI: 10.1088/1361-6528/abaadb]
Decuzzi, Paolo
Peer, Dan
Di Mascolo, Daniele
Palange, Anna Lisa
Manghnani, Purnima Naresh
Moghimi, S. Moein
Farhangrazi, Z. Shadi
Howard, Kenneth A.
Rosenblum, Daniel
Liang, Tingxizi
Chen, Zhaowei
Wang, Zejun
Zhu, Jun-Jie
Gu, Zhen
Korin, Netanel
Letourneur, Didier
Chauvierre, Cédric
van der Meel, Roy
Kiessling, Fabian
Lammers, Twan
[Journal Article]
Automation of data analysis in molecular cancer imaging and its potential impact on future clinical practice
In: Methods, 2020
[DOI: 10.1016/j.ymeth.2020.06.019]
Theek, Benjamin
Magnuska, Zuzanna
Gremse, Felix
Hahn, Horst
Schulz, Volkmar
Kiessling, Fabian
[Journal Article]
A collagen-binding protein enables molecular imaging of kidney fibrosis in vivo
In: Kidney international, 97 (3), 609-614, 2020
[DOI: 10.1016/j.kint.2019.08.029]
Baues, Maike
Klinkhammer, Barbara M.
Ehling, Josef
Gremse, Felix
van Zandvoort, Marc A. M. J.
Reutelingsperger, Chris P. M.
Daniel, Christoph
Amann, Kerstin
Bábí?ková, Janka
Kiessling, Fabian
Floege, Jürgen
Lammers, Twan
Boor, Peter
[Journal Article]
Hybrid MPI-MRI System for Dual-Modal In Situ Cardiovascular Assessments of Real-Time 3D Blood Flow Quantification-A Pre-Clinical In Vivo Feasibility Investigation
In: EEE transactions on medical imaging, 39 (12), 4335-4345, 2020
[DOI: 10.1109/TMI.2020.3017160]
Franke, Jochen
Baxan, Nicoleta
Lehr, Heinrich
Heinen, Ulrich
Reinartz, Sebastian
Schnorr, Jorg
Heidenreich, Michael
Kiessling, Fabian
Schulz, Volkmar
[Journal Article]
Lumenal calcification and microvasculopathy in fetuin-A-deficient mice lead to multiple organ morbidity
In: PLoS one, 15 (2), e0228503, 2020
[DOI: 10.1371/journal.pone.0228503]
Herrmann, Marietta
Babler, Anne
Moshkova, Irina
Gremse, Felix
Kiessling, Fabian
Kusebauch, Ulrike
Nelea, Valentin
Kramann, Rafael
Moritz, Robert L.
McKee, Marc D.
Jahnen-Dechent, Willi
[Journal Article]
Optical imaging of the whole-body to cellular biodistribution of clinical-stage PEG-b-pHPMA-based core-crosslinked polymeric micelles
In: Journal of controlled release, 328, 805-816, 2020
[DOI: 10.1016/j.jconrel.2020.09.046]
Biancacci, Ilaria
Sun, Qingxue
Möckel, Diana
Gremse, Felix
Rosenhain, Stefanie
Kiessling, Fabian
Bartneck, Matthias
Hu, Qizhi
Thewissen, Marielle
Storm, Gert
Hennink, Wim E.
Shi, Yang
Rijcken, Cristianne J. F.
Lammers, Twan
Sofias, Alexandros Marios
[Journal Article]
Breaking medical data sharing boundaries by using synthesized radiographs
In: Science advances, 6 (49), eabb7973, 2020
[DOI: 10.1126/sciadv.abb7973]
Han, Tianyu
Nebelung, Sven
Haarburger, Christoph
Horst, Nicolas
Reinartz, Sebastian
Merhof, Dorit
Kiessling, Fabian
Schulz, Volkmar (Corresponding author)
Truhn, Daniel
[Journal Article]
Emerging methods in radiology
In: Der Radiologe, 60 (Suppl 1), 41-53, 2020
[DOI: 10.1007/s00117-020-00696-0]
Theek, Benjamin
Nolte, T.
Pantke, D.
Schrank, F.
Gremse, Felix
Schulz, V.
Kiessling, Fabian (Corresponding author)
[Contribution to a book, Journal Article]
Photoacoustic Imaging Probes Based on Tetrapyrroles and Related Compounds
In: International journal of molecular sciences, 21 (9), 3082, 2020
[DOI: 10.3390/ijms21093082]
Merkes, Jean Michél
Zhu, Leiming
Bahukhandi, Srishti Ballabh
Rüping, Magnus
Kiessling, Fabian
Banala, Srinivas (Corresponding author)
[Journal Article]
Tuning Optical Properties of BODIPY Dyes by Pyrrole Conjugation for Photoacoustic Imaging
In: Advanced optical materials, 8 (11), 1902115, 2020
[DOI: 10.1002/adom.201902115]
Merkes, Jean Michél
Lammers, Twan
Kancherla, R.
Rüping, Magnus
Kiessling, Fabian
Banala, Srinivas (Corresponding author)
[Journal Article]
Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance
In: Journal of nanobiotechnology, 18, 22, 2020
[DOI: 10.1186/s12951-020-0580-1]
Dadfar, Seyed Mohammadali
Camozzi, Denise
Darguzyte, Milita
Roemhild, Karolin
Varvarà, Paola
Metselaar, Josbert M.
Banala, Srinivas
Straub, Marcel
Güvener, Nihan
Engelmann, Ulrich
Slabu, Ioana
Buhl, Miriam
van Leusen, Jan
Kögerler, Paul
Hermanns-Sachweh, Benita
Schulz, Volkmar
Kiessling, Fabian
Lammers, Twan (Corresponding author)
[Journal Article]
Cell barrier characterization in transwell inserts by electrical impedance spectroscopy
In: Biosensors and Bioelectronics, 165, 112345, 2020
[DOI: 10.1016/j.bios.2020.112345]
Linz, Georg Franz
Djeljadini, Suzana
Steinbeck, Lea
Köse, Gurbet
Kiessling, Fabian
Wessling, Matthias (Corresponding author)
[Journal Article]
Dexamethasone nanomedicines for COVID-19
In: Nature nanotechnology, 15 (8), 622-624, 2020
[DOI: 10.1038/s41565-020-0752-z]
Lammers, Twan
Sofias, Alexandros Marios
van der Meel, Roy
Schiffelers, Raymond
Storm, Gert
Tacke, Frank
Koschmieder, Steffen
Brümmendorf, Tim H.
Kiessling, Fabian
Metselaar, Josbert M.
[Journal Article]
Influence of MRI Examinations on Animal Welfare and Study Results
In: Investigative radiology, 55 (8), 507-514, 2020
[DOI: 10.1097/RLI.0000000000000669]
Baier, Jasmin
Rix, Anne
Drude, Natascha Ingrid
Darguzyte, Milita
Baues, Maike
May, Jan-Niklas
Schipper, Sandra
Möckel, Diana
Palme, Rupert
Tolba, René
Kiessling, Fabian
[Journal Article]
Corrigendum: Evaluation of Riboflavin Transporters as Targets for Drug Delivery and Theranostics
In: Frontiers in pharmacology, 11, 617329, 2020
[DOI: 10.3389/fphar.2020.617329]
Bartmann, Lisa
Schumacher, David
von Stillfried, Saskia
Sternkopf, Marieke
Alampour-Rajabi, Setareh
van Zandvoort, Marc A. M. J.
Kiessling, Fabian
Wu, Zhuojun
[Journal Article]
Drug Loading in Poly(butyl cyanoacrylate)-Based Polymeric Microbubbles
In: Molecular pharmaceutics, 17 (8), 2840-2848, 2020
[DOI: 10.1021/acs.molpharmaceut.0c00242]
Liu, Mengjiao
Dasgupta, Anshuman
Koczera, Patrick
Schipper, Sandra
Rommel, Dirk
Shi, Yang
Kiessling, Fabian
Lammers, Twan
[Journal Article]
Multimodal and multiscale optical imaging of nanomedicine delivery across the blood-brain barrier upon sonopermeation
In: Theranostics, 10 (4), 1948-1959, 2020
[DOI: 10.7150/thno.41161]
May, Jan-Niklas
Golombek, Susanne K.
Baues, Maike
Dasgupta, Anshuman
Drude, Natascha
Rix, Anne
Rommel, Dirk
von Stillfried, Saskia
Appold, Lia
Pola, Robert
Pechar, Michal
van Bloois, Louis
Storm, Gert
Kuehne, Alexander J. C.
Gremse, Felix
Theek, Benjamin
Kiessling, Fabian
Lammers, Twan
[Journal Article]
Cancer nanomedicine meets immunotherapy: opportunities and challenges
In: Acta pharmacologica Sinica : APS, 41, 954-958, 2020
[DOI: 10.1038/s41401-020-0448-9]
Sun, Qingxue
Bai, Xiangyang
Sofias, Alexandros Marios
van der Meel, Roy
Ruiz-Hernandez, Eduardo
Storm, Gert
Hennink, Wim E.
De Geest, Bruno G.
Kiessling, Fabian
Yu, Hai-Jun
Lammers, Twan (Corresponding author)
Shi, Yang (Corresponding author)
[Journal Article]
Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles
In: Journal of the American Chemical Society, 142 (28), 12133-12139, 2020
[DOI: 10.1021/jacs.0c01928]
Wang, Bi
Van Herck, Simon
Chen, Yong
Bai, Xiangyang
Zhong, Zifu
Deswarte, Kim
Lambrecht, Bart N.
Sanders, Niek N.
Lienenklaus, Stefan
Scheeren, Hans W.
David, Sunil A.
Kiessling, Fabian
Lammers, Twan (Corresponding author)
De Geest, Bruno G.
Shi, Yang (Corresponding author)
[Journal Article]
Influence of Riboflavin Targeting on Tumor Accumulation and Internalization of Peptostar Based Drug Delivery Systems
In: Bioconjugate chemistry, 31 (12), 2691-2696, 2020
[DOI: 10.1021/acs.bioconjchem.0c00593]
Darguzyte, Milita
Holm, Regina
Baier, Jasmin
Drude, Natascha Ingrid
Schultze, Jennifer
Koynov, Kaloian
Schwiertz, David
Dadfar, Seyed Mohammadali
Lammers, Twan
Barz, Matthias
Kiessling, Fabian (Corresponding author)
[Journal Article]
What scans we will read: imaging instrumentation trends in clinical oncology
In: Cancer Imaging, 20 (1), 38, 2020
[DOI: 10.1186/s40644-020-00312-3]
Beyer, Thomas (Corresponding author)
Bidaut, Luc
Dickson, John
Kachelriess, Marc
Kiessling, Fabian
Leitgeb, Rainer
Ma, Jingfei
Shiyam Sundar, Lalith Kumar
Theek, Benjamin
Mawlawi, Osama
[Contribution to a book, Journal Article]
Riboflavin-Targeted Drug Delivery
In: Cancers, 12 (2), 295, 2020
[DOI: 10.3390/cancers12020295]
Darguzyte, Milita
Drude, Natascha
Lammers, Twan
Kiessling, Fabian (Corresponding author)
[Journal Article]
Quo Vadis, Molecular Imaging?
In: Journal of nuclear medicine : JNM, 61 (10), 1428-1434, 2020
[DOI: 10.2967/jnumed.120.241984]
Grimm, Jan (Corresponding author)
Kiessling, Fabian
Pichler, Bernd J.
[Contribution to a book, Journal Article]
Molecular Ultrasound Imaging
In: Nanomaterials : open access journal, 10 (10), 1935, 2020
[DOI: 10.3390/nano10101935]
Köse, Gurbet
Darguzyte, Milita
Kiessling, Fabian (Corresponding author)
[Journal Article]
Implementation of eHealth and AI integrated diagnostics with multidisciplinary digitized data : are we ready from an international perspective?
In: European radiology, 30 (10), 5510-5524, 2020
[DOI: 10.1007/s00330-020-06874-x]
Bukowski, Mark
Farkas, Robert (Corresponding author)
Beyan, Oya Deniz
Moll, Lorna
Hahn, Horst
Kiessling, Fabian (Corresponding author)
Schmitz-Rode, Thomas (Corresponding author)
[Contribution to a book, Journal Article]
Ultrasound Microbubbles for Diagnosis and Treatment of Cardiovascular Diseases
In: Seminars in thrombosis and hemostasis, 46 (5), 545-552, 2019, 2020
[DOI: 10.1055/s-0039-1688492]
Rix, Anne
Curaj, Adelina
Liehn, Elisa Anamaria
Kiessling, Fabian (Corresponding author)
[Journal Article]
Super-resolution Ultrasound Imaging
In: Ultrasound in medicine & biology, 46 (4), 865-891, 2020
[DOI: 10.1016/j.ultrasmedbio.2019.11.013]
Christensen-Jeffries, Kirsten
Couture, Olivier (Corresponding author)
Dayton, Paul A.
Eldar, Yonina C.
Hynynen, Kullervo
Kiessling, Fabian
O'Reilly, Meaghan
Pinton, Gianmarco F.
Schmitz, Georg
Tang, Meng-Xing
Tanter, Mickael
van Sloun, Ruud J. G.
[Contribution to a book, Journal Article]
Design of a joint research data platform : A use case for severity assessment
In: Laboratory animals, 54 (1), 33-39, 2019, 2020
[DOI: 10.1177/0023677219872228]
Talbot, Steven R. (Corresponding author)
Bruch, Stefan
Kiessling, Fabian
Marschollek, Michael
Jandric, Branko
Tolba, René H.
Bleich, André
[Journal Article]
Assessment of Chemotherapy-Induced Organ Damage with Ga-68 Labeled Duramycin
In: Molecular imaging & biology : MIB, 22 (3), 623-633, 2019, 2020
[DOI: 10.1007/s11307-019-01417-3]
Rix, Anne
Drude, Natascha Ingrid
Mrugalla, Anna
Baskaya, Ferhan
Pak, Koon Yan
Gray, Brian
Kaiser, Hans-Jürgen
Tolba, René Hany
Fiegle, Eva
Lederle, Wiltrud
Mottaghy, Felix Manuel
Kiessling, Fabian
[Journal Article]
Molecular Imaging Unravels Cerebral Malaria
In: Radiology, 290 (2), 368-369, 2019
[DOI: 10.1148/radiol.2018182461]
Kiessling, Fabian
[Journal Article]
Evaluation of Riboflavin Transporters as Targets for Drug Delivery and Theranostics
In: Frontiers in pharmacology, 10, 79, 2019
[DOI: 10.3389/fphar.2019.00079]
Bartmann, Lisa
Schumacher, David
von Stillfried, Saskia
Sternkopf, Marieke
Alampour-Rajabi, Setareh
van Zandvoort, Marc A. M. J.
Kiessling, Fabian
Wu, Zhuojun
[Journal Article]
Perspective review of optical imaging in welfare assessment in animal-based research
In: Journal of biomedical optics, 24 (7), 1-11, 2019
[DOI: 10.1117/1.JBO.24.7.070601]
Pereira, Carina
Kunczik, Janosch
Bleich, André
Haeger, Christine
Kiessling, Fabian
Thum, Thomas
Tolba, René
Lindauer, Ute
Treue, Stefan
Czaplik, Michael
[Journal Article]
MR and PET-CT monitoring of tissue-engineered vascular grafts in the ovine carotid artery
In: Biomaterials : biomaterials reviews online, 216, 119228, 2019
[DOI: 10.1016/j.biomaterials.2019.119228]
Wolf, F.
Paefgen, V.
Winz, O.
Mertens, M.
Koch, S.
Gross-Weege, N.
Morgenroth, A.
Rix, A.
Schnoering, H.
Chalabi, K.
Jockenhoevel, S.
Lammers, T.
Mottaghy, F.
Kiessling, F.
Mela, P.
[Journal Article]
Photoacoustic Detection of Superoxide Using Oxoporphyrinogen and Porphyrin
In: ACS sensors, 4 (8), 2001-2008, 2019
[DOI: 10.1021/acssensors.9b00224]
Merkes, Jean Michél
Rueping, Magnus
Kiessling, Fabian
Banala, Srinivas
[Journal Article]
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
In: Advanced drug delivery reviews, 138, 302-325, 2019
[DOI: 10.1016/j.addr.2019.01.005]
Dadfar, Seyed Mohammadali
Roemhild, Karolin
Drude, Natascha I.
von Stillfried, Saskia
Knüchel, Ruth
Kiessling, Fabian
Lammers, Twan
[Journal Article]
Liver fibrosis affects the targeting properties of drug delivery systems to macrophage subsets in vivo
In: Biomaterials, 206, 49-60, 2019
[DOI: 10.1016/j.biomaterials.2019.03.025]
Ergen, Can
Niemietz, Patricia Maria
Heymann, Felix
Baues, Maike
Gremse, Felix
Pola, Robert
van Bloois, Louis
Storm, Gert
Kiessling, Fabian
Trautwein, Christian
Luedde, Tom
Lammers, Twan
Tacke, Frank
[Journal Article]
Characterizing responsive and refractory orthotopic mouse models of hepatocellular carcinoma in cancer immunotherapy
In: PLoS one, 14 (7), e0219517, 2019
[DOI: 10.1371/journal.pone.0219517]
Hage, Carina
Hoves, Sabine
Ashoff, Mailin
Schandl, Veronika
Hört, Stefan
Rieder, Natascha
Heichinger, Christian
Berrera, Marco
Ries, Carola H.
Kiessling, Fabian
Pöschinger, Thomas
[Journal Article]
Shelf-Life Evaluation and Lyophilization of PBCA-Based Polymeric Microbubbles
In: Pharmaceutics, 11 (9), 2019
[DOI: 10.3390/pharmaceutics11090433]
Ojha, Tarun
Pathak, Vertika
Drude, Natascha
Weiler, Marek
Rommel, Dirk
Rütten, Stephan
Geinitz, Bertram
van Steenbergen, Mies J.
Storm, Gert
Kiessling, Fabian
Lammers, Twan
[Journal Article]
Sorafenib Induces Pyroptosis in Macrophages and Triggers Natural Killer Cell-Mediated Cytotoxicity Against Hepatocellular Carcinoma
In: Hepatology : official journal of the American Association for the Study of Liver Diseases, 70 (4), 1280-1297, 2019
[DOI: 10.1002/hep.30666]
Hage, Carina (Corresponding author)
Hoves, Sabine
Strauss, Léanne
Bissinger, Stefan
Prinz, Ylva
Pöschinger, Thomas
Kiessling, Fabian (Corresponding author)
Ries, Carola H.
[Journal Article]
The CCR2 Macrophage Subset Promotes Pathogenic Angiogenesis for Tumor Vascularization in Fibrotic Livers
In: Cellular and Molecular Gastroenterology and Hepatology : CMGH, 7 (2), 371-390, 2019
[DOI: 10.1016/j.jcmgh.2018.10.007]
Bartneck, Matthias
Schrammen, Peter L.
Möckel, Diana
Govaere, Olivier
Liepelt, Anke
Krenkel, Oliver
Ergen, Can
McCain, Misti Vanette
Eulberg, Dirk
Luedde, Tom
Trautwein, Christian
Kiessling, Fabian
Reeves, Helen
Lammers, Twan
Tacke, Frank (Corresponding author)
[Journal Article]
PET performance evaluation of the small-animal Hyperion II PET/MRI insert based on the NEMA NU-4 standard
In: Biomedical physics & engineering express, 4 (6), 065027, 2018
[DOI: 10.1088/2057-1976/aae6c2]
Hallen, Patrick
Schug, David
Weissler, Bjoern
Gebhardt, Pierre
Salomon, André
Kiessling, Fabian
Schulz, Volkmar
[Contribution to a conference proceedings, Journal Article]
Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors
In: Journal of controlled release, 282, 25-34, 2018
[DOI: 10.1016/j.jconrel.2018.05.002]
Theek, Benjamin
Baues, Maike
Gremse, Felix
Pola, Robert
Pechar, Michal
Negwer, Inka
Koynov, Kaloian
Weber, Benjamin
Barz, Matthias
Jahnen-Dechent, Wilhelm
Storm, Gert
Kiessling, Fabian
Lammers, Twan (Corresponding author)
[Journal Article]
Semi-Automated Segmentation of the Tumor Vasculature in Contrast-Enhanced Ultrasound Data
In: Ultrasound in medicine & biology, 44 (8), 1910-1917, 2018
[DOI: 10.1016/j.ultrasmedbio.2018.03.015]
Theek, Benjamin
Opačić, Tatjana
Lammers, Twan
Kiessling, Fabian (Corresponding author)
[Journal Article]
Radiomic analysis of contrast-enhanced ultrasound data
In: Scientific reports, 8, 11359, 2018
[DOI: 10.1038/s41598-018-29653-7]
Theek, Benjamin
Opacic, Tatjana
Magnuska, Zuzanna
Lammers, Twan
Kiessling, Fabian (Corresponding author)
[Journal Article]
A preclinical micro-computed tomography database including 3D whole body organ segmentations
In: Scientific data, 5, 180294, 2018
[DOI: 10.1038/sdata.2018.294]
Rosenhain, Stefanie (Corresponding author)
Magnuska, Zuzanna A.
Yamoah, Grace G.
Rawashdeh, Wa'el Al
Kiessling, Fabian
Gremse, Felix
[Journal Article]
Clinical Pilot Application of Super-Resolution US Imaging in Breast Cancer
In: IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 66 (3), 517-526, 2018
[DOI: 10.1109/TUFFC.2018.2872067]
Dencks, Stefanie
Piepenbrock, Marion
Opačić, Tatjana
Krauspe, Barbara
Stickeler, Elmar
Kiessling, Fabian (Corresponding author)
Schmitz, Georg
[Book]
Small Animal Imaging : Basics and Practical Guide
In: Springer eBook Collection. Medicine, 2017
[DOI: 10.1007/978-3-319-42202-2]
Kiessling, Fabian (Editor)
Pichler, Bernd J. (Editor)
Hauff, Peter (Editor)
[Journal Article]
Multi-photon microscopy in cardiovascular research
In: Methods, 130, 79-89, 2017
[DOI: 10.1016/j.ymeth.2017.04.013]
Wu, Zhuojun
Rademakers, Timo
Kiessling, Fabian
Vogt, Michael
Westein, Erik
Weber, Christian
Megens, Remco T. A.
van Zandvoort, Marc
[Contribution to a book, Journal Article]
Fibrosis imaging: Current concepts and future directions
In: Advanced drug delivery reviews, 121, 9-26, 2017
[DOI: 10.1016/j.addr.2017.10.013]
Baues, Maike
Dasgupta, Anshuman
Ehling, Josef
Prakash, Jai
Boor, Peter
Tacke, Frank
Kiessling, Fabian
Lammers, Twan (Corresponding author)
[Contribution to a book, Journal Article]
Pharmacological and physical vessel modulation strategies to improve EPR-mediated drug targeting to tumors☆
In: Advanced drug delivery reviews, 119, 44-60, 2017
[DOI: 10.1016/j.addr.2017.07.007]
Ojha, Tarun
Pathak, Vertika
Shi, Yang
Hennink, Wim E.
Moonen, Chrit T. W.
Storm, Gert
Kiessling, Fabian (Corresponding author)
Lammers, Twan (Corresponding author)
[Journal Article]
Enhancing Tumor Penetration of Nanomedicines
In: Biomacromolecules, 18 (5), 1449-1459, 2017
[DOI: 10.1021/acs.biomac.7b00068]
Sun, Qingxue
Ojha, Tarun
Kiessling, Fabian
Lammers, Twan
Shi, Yang
[Journal Article]
Photoacoustic imaging of tumor targeting with riboflavin-functionalized theranostic nanocarriers
In: International journal of nanomedicine, 12, 3813-3825, 2017
[DOI: 10.2147/IJN.S125192]
Beztsinna, Nataliia
Tsvetkova, Yoanna
Jose, Jithin
Rhourri-Frih, Boutayna
Al Rawashdeh, Wa'el
Lammers, Twan
Kiessling, Fabian (Corresponding author)
Bestel, Isabelle (Corresponding author)
[Journal Article]
Singlet oxygen-responsive micelles for enhanced photodynamic therapy
In: Journal of controlled release, 260, 12-21, 2017
[DOI: 10.1016/j.jconrel.2017.05.025]
Li, Xiaodan
Gao, Min
Xin, Keting
Zhang, Ling
Ding, Dan
Kong, Deling
Wang, Zheng
Shi, Yang
Kiessling, Fabian
Lammers, Twan
Cheng, Jianjun
Zhao, Yanjun (Corresponding author)
[Journal Article]
Recent advances in ultrasound-based diagnosis and therapy with micro- and nanometer-sized formulations
In: Methods, 130, 4-13, 2017
[DOI: 10.1016/j.ymeth.2017.05.018]
Güvener, Nihan
Appold, Lia
de Lorenzi, Federica
Golombek, Susanne K.
Rizzo, Larissa Y.
Lammers, Twan
Kiessling, Fabian
[Journal Article]
Science to Practice: Multiparametric Molecular and Functional US Imaging Goes Three-dimensional
In: Radiology, 282 (2), 307-309, 2017
[DOI: 10.1148/radiol.2016161455]
Kiessling, Fabian
[Journal Article]
Balancing Passive and Active Targeting to Different Tumor Compartments Using Riboflavin-Functionalized Polymeric Nanocarriers
In: Nano letters, 17 (8), 4665-4674, 2017
[DOI: 10.1021/acs.nanolett.7b01171]
Tsvetkova, Yoanna (Corresponding author)
Beztsinna, Nataliia
Baues, Maike
Klein, Dionne
Rix, Anne
Golombek, Susanne K.
Al Rawashdeh, Wa'el
Gremse, Felix
Barz, Matthias
Koynov, Kaloian
Banala, Srinivas
Lederle, Wiltrud
Lammers, Twan
Kiessling, Fabian
[Journal Article]
Nilotinib Enhances Tumor Angiogenesis and Counteracts VEGFR2 Blockade in an Orthotopic Breast Cancer Xenograft Model with Desmoplastic Response
In: Neoplasia, 19 (11), 896-907, 2017
[DOI: 10.1016/j.neo.2017.08.009]
Zafarnia, Sara
Bzyl-Ibach, Jessica
Spivak, Igor
Li, Yongping
Koletnik, Susanne
Doleschel, Dennis
Rix, Anne
Pochon, Sibylle
Tardy, Isabelle
Koyadan, Seena
van Zandvoort, Marc
Palmowski, Moritz
Kiessling, Fabian
Lederle, Wiltrud (Corresponding author)
[Journal Article]
Granzyme B-based cytolytic fusion protein targeting EpCAM specifically kills triple negative breast cancer cells in vitro and inhibits tumor growth in a subcutaneous mouse tumor model
In: Cancer letters, 372 (2), 201-209, 2016
[DOI: 10.1016/j.canlet.2016.01.027]
Amoury, Manal
Kolberg, Katharina
Pham, Anh-Tuan
Hristodorov, Dmitrij
Mladenov, Radoslav
Di Fiore, Stefano
Helfrich, Wijnand
Kiessling, Fabian
Fischer, Rainer
Pardo, Alessa
Thepen, Theophilus
Hussain, Ahmad Fawzi
Nachreiner, Thomas
Barth, Stefan (Corresponding author)
[Journal Article]
Longitudinal imaging of the ageing mouse
In: Mechanisms of ageing and development, 160, 93-116, 2016
[DOI: 10.1016/j.mad.2016.08.001]
Dall'Ara, E. (Corresponding author)
Boudiffa, M.
Taylor, C.
Schug, David
Fiegle, E.
Kennerley, A. J.
Damianou, C.
Tozer, G. M.
Kiessling, Fabian
Müller, R.
[Journal Article]
Applications of nanoparticles for diagnosis and therapy of cancer
In: The British journal of radiology, 88 (1054), 20150207, 2015
[DOI: 10.1259/bjr.20150207]
Baetke, S. C.
Lammers, T.
Kiessling, Fabian
[Journal Article]
Sunitinib microspheres based on [PDLLA-PEG-PDLLA]-b-PLLA multi-block copolymers for ocular drug delivery
In: European journal of pharmaceutics and biopharmaceutics, 95 (Pt B), 368-377, 2015
[DOI: 10.1016/j.ejpb.2015.02.011]
Ramazani, F.
Hiemstra, C.
Steendam, R.
Kazazi-Hyseni, F.
van Nostrum, C. F.
Storm, G.
Kiessling, Fabian
Lammers, T.
Hennink, W. E.
Kok, R. J. (Corresponding author)
[Journal Article]
Molekulare Ultraschallbildgebung : Chancen für die Klinik
In: Der Radiologe : Zeitschrift für diagnostische und interventionelle Radiologie, Radioonkologie, Nuklearmedizin, 55 (11), 956-963, 2015
[DOI: 10.1007/s00117-015-0023-4]
Rix, A.
Palmowski, M.
Kiessling, Fabian (Corresponding author)
[Journal Article]
Nanoparticles for Imaging: Top or Flop? (vol 273, pg 10, 2014)
In: Radiology, 274 (1), 307-307, 2015
[DOI: 10.1148/radiol.14144049]
Kiessling, Fabian
[Journal Article]
Differential contrast of gold nanorods in dual-band OCT using spectral multiplexing
In: Journal of nanoparticle research, 17 (3), 138, 2015
[DOI: 10.1007/s11051-015-2949-x]
Al Rawashdeh, Wa'el
Weyand, Thomas
Kray, Stefan
Lenz, Markus
Buchkremer, Anne
Spöler, Felix
Simon, Ulrich
Möller, Martin
Kiessling, Fabian
Lederle, Wiltrud (Corresponding author)
[Journal Article]
Image-guided drug delivery : preclinical applications and clinical translation
In: Expert opinion on drug delivery, 12 (8), 1203-1207, 2015
[DOI: 10.1517/17425247.2015.1059420]
Ojha, Tarun
Rizzo, Larissa
Storm, Gert
Kiessling, Fabian
Lammers, Twan (Corresponding author)
[Journal Article]
MR-compatibility assessment of the first preclinical PET-MRI insert equipped with digital silicon photomultipliers
In: Physics in medicine and biology, 60 (6), 2231-2255, 2015
[DOI: 10.1088/0031-9155/60/6/2231]
Wehner, Jakob (Corresponding author)
Weissler, B.
Dueppenbecker, P. M.
Gebhardt, P.
Goldschmidt, B.
Schug, D.
Kiessling, Fabian
Schulz, Volker (Corresponding author)
[Journal Article]
Formulation and characterization of microspheres loaded with imatinib for sustained delivery
In: International journal of pharmaceutics, 482 (1-2), 123-130, 2015
[DOI: 10.1016/j.ijpharm.2015.01.043]
Ramazani, F.
Chen, W.
Van Nostrum, C. F.
Storm, G.
Kiessling, Fabian
Lammers, T.
Hennink, W. E.
Kok, R. J. (Corresponding author)
[Journal Article]
Flexible and Modular MPI Simulation Framework and Its Use in Modeling a μ MPI
In: IEEE transactions on magnetics, 51 (2), 1-4, 2015
[DOI: 10.1109/TMAG.2014.2329733]
Straub, Marcel (Corresponding author)
Lammers, Twan
Kiessling, Fabian
Schulz, Volkmar
[Journal Article]
A Field Cancellation Signal Extraction Method for Magnetic Particle Imaging
In: IEEE transactions on magnetics, 51 (2), 1-4, 2015
[DOI: 10.1109/TMAG.2014.2325852]
Schulz, Volkmar (Corresponding author)
Straub, Marcel
Mahlke, Max
Hubertus, Simon
Lammers, Twan
Kiessling, Fabian
[Journal Article]
In-vivo detection of the erythropoietin receptor in tumours using positron emission tomography
In: European radiology, 25 (2), 472-479, 2015
[DOI: 10.1007/s00330-014-3413-5]
Fuge, Felix
Doleschel, Dennis
Rix, Anne
Gremse, Felix
Wessner, Axel
Winz, Oliver
Mottaghy, Felix Manuel
Lederle, Wiltrud
Kiessling, Fabian (Corresponding author)
[Journal Article]
Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury
In: Journal of hepatology, 62 (1), 140-149, 2015
[DOI: 10.1016/j.jhep.2014.08.029]
Cubero, Francisco Javier
Zhao, Gang
Nevzorova, Yulia A.
Hatting, Maximilian
Al Masaoudi, Malika
Verdier, Julien
Peng, Jin
Schaefer, Frederik M.
Hermanns, Nadine
Boekschoten, Mark V.
Grouls, Christoph
Gaßler, Nikolaus
Kiessling, Fabian
Muller, Michael
Davis, Roger J.
Liedtke, Christian
Trautwein, Christian (Corresponding author)
[Journal Article]
Dynamic Contrast-Enhanced Ultrasound Parametric Maps to Evaluate Intratumoral Vascularization
In: Investigative radiology : a journal of clinical and laboratory research, 2014, 2015
[DOI: 10.1097/RLI.0000000000000101]
Pitre-Champagnat, Stephanie (Corresponding author)
Leguerney, Ingrid
Bosq, Jacques
Peronneau, Pierre
Kiessling, Fabian
Calmels, Lucie
Coulot, Jeremy
Lassau, Nathalie
[Journal Article]
FMN-coated fluorescent USPIO for cell labeling and non-invasive MR imaging in tissue engineering
In: Theranostics, 4 (10), 1002-1013, 2014
[DOI: 10.7150/thno.8763]
Mertens, Marianne E.
Frese, Julia
Bölükbas, Deniz Ali
Hrdlicka, Ladislav
Golombek, Susanne
Koch, Sabine
Mela, Petra
Jockenhövel, Stefan
Kiessling, Fabian (Corresponding author)
Lammers, Twan (Corresponding author)
[Contribution to a book, Journal Article, Poster]
Non-invasive monitoring of tissue-engineered vascular endothelium
In: Mitteilungen / Institut für Textiltechnik, 60.2013, 1 S., 2014
Frese, Julia (Corresponding author)
Hrdlicka, Ladislav
Mertens, M. E.
Rongen, Lisanne
Koch, Sabine
Schuster, Philipp
Gesché, Valentine
Lammers, Twan
Mela, Petra
Kiessling, Stephan
Jockenhövel, Stefan
[Abstract, Contribution to a conference proceedings, Journal Article]
Variability of intrahepatic vascular anatomy in rodents & their surgical implications
In: Transplant international, 27 (Suppl. s3), Poster Abstracts, 43-43, 2014
Sänger, C.
Schenk, A.
Schwen, L. O.
Wang, L.
Gremse, F.
Zafarnia, S.
Kiessling, Fabian
Wei, W.
Richter, B.
Dahmen, U.
[Abstract, Contribution to a conference proceedings, Journal Article]
Three-dimensional reconstruction of the architecture of the biliary tree during cholestasis
In: Journal of hepatology, 58 (Suppl. 1), S282-S282, 2013
[DOI: 10.1016/S0168-8278(13)60697-2]
Richter, B.
Dirsch, O.
Gremse, F.
Zarafina, S.
Kiessling, Fabian
Settmacher, U.
Dahmen, U.
[Journal Article]
Molecular ultrasound imaging and its potential for paediatric radiology
In: Pediatric radiology, 41 (2), 176-184, 2011
[DOI: 10.1007/s00247-010-1779-3]
Kiessling, Isabel
Bzyl, Jessica
Kießling, Fabian
[Journal Article]
TNF-alpha and the IFN-gamma-inducible protein 10 (IP-10/CXCL-10) delivered by parvoviral vectors act in synergy to induce antitumor effects in mouse glioblastoma
In: Cancer gene therapy, 16 (2), 149-160, 2009
[DOI: 10.1038/cgt.2008.62]
Enderlin, M.
Kleinmann, E. V.
Struyf, S.
Buracchi, C.
Vecchi, A.
Kinscherf, R.
Kiessling, Fabian
Paschek, S.
Sozzani, S.
Rommelaere, J.
Cornelis, J. J.
van Damme, J.
Dinsart, C.