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Copyright: © Private

Person

Univ.-Prof. Dr. sc. hum.

Twan Lammers

Chair of Experimental Molecular Imaging

Address

Building: 5710

Room: 104

Forckenbeckstr. 55

52074 Aachen

Contact

WorkPhone

Phone: +49 241 80 85907

Email: tlammers@ukaachen.de

Website

Twan Lammers obtained a D.Sc. in Radiation Oncology from Heidelberg University in 2008 and a Ph.D. in Pharmaceutics from Utrecht University in 2009. In the same year, he started the Nanomedicine and Theranostics group at the Institute for Experimental Molecular Imaging (ExMI) at RWTH Aachen University Clinic. In 2014, he was promoted to full professor of medicine. His group aims to individualize and improve disease treatment by combining drug targeting with imaging. To this end, image-guided (theranostic) drug delivery systems are being developed, as well as materials and methods to monitor tumor growth, angiogenesis, inflammation, fibrosis and metastasis. He has published over 250 papers, and received multiple scholarships and awards, including a starting and consolidator grant from the European Research Council, the Young Investigator Award of the Controlled Release Society (2015), the Adritelf International Award (2015) and the Belgian Society for Pharmaceutical Science International Award (2020). He is on the editorial board of 10 journals, and serves as a handling editor for the Journal of Controlled Release, Drug Delivery and Translational Research, and Molecular Imaging and Biology. Since 2019, he is included in the Clarivate Analytics list of Highly Cited Researchers.

Selected publications:

1. Sun Q, Baues M, Klinkhammer B, Ehling J, Djudjaj S, Drude N, Daniel C, Amann K, Kramann R, Kim H, Saez-Rodriguez J, Weiskirchen R, Onthank D, Botnar R, Kiessling F, Floege J, Lammers T*, Boor P*. Elastin imaging enables non-invasive staging and treatment monitoring of kidney fibrosis. Science Translational Medicine 11, eaat4865 (2019)
2. Van der Meel R, Sulheim E, Shi Y, Kiessling F, Mulder W, Lammers T*. Smart cancer nanomedicine. Nature Nanotechnology 14, 1007-1017 (2019)
3. Biancacci I, Sun Q, Möckel D, Gremse F, Rosenhain S, Kiessling F, Bartneck M, Hu Q, Thewissen M, Storm G, Hennink WE, Shi Y, Rijcken CJF, Lammers T*, Sofias A*. Optical imaging of the whole-body to cellular biodistribution of clinical-stage PEG-b-pHPMA-based core-crosslinked polymeric micelles. Journal of Controlled Release 328: 805-816 (2020)
4. Dadfar S, Camozzi D, Darguzyte M, Roemhild K, Varvarà P, Metselaar J, Banala S, Straub M, Güvener N, Engelmann U, Slabu I, Buhl M, van Leusen J, Kögerler P, Hermanns-Sachweh B, Schulz V, Kiessling F, Lammers T*. Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance. Journal of Nanobiotechnology 18, 22 (2020)
5. Lammers T*, Sofias A, Meel R, Schiffelers R, Storm G, Tacke F, Koschmieder S, Brümmendorf T, Kiessling F, Metselaar J*. Dexamethasone nanomedicines for COVID-19. Nature Nanotechnology 15, 622-624 (2020)
6. May J, Golombek S, Baues M, Dasgupta A, Drude N, Rix A, Rommel D, Stilfried S, Appold L, Pola R, Pechar M, Bloois L, Storm G, Kuehne A, Gremse F, Theek B, Kiessling F, Lammers T*. Multimodal and multiscale optical imaging of nanomedicine delivery across the blood-brain barrier upon sonopermeation. Theranostics 10, 1948-1959 (2020)
7. Wang B, Van Herck S, Chen Y, Bai X, Zhong Z, De Swarte K, Lambrecht B, Sanders N, Lienenklaus S, Scheeren H, David S, Kiessling F, Lammers T*, De Geest B*, Shi Y*. Potent and prolonged innate immune activation by enzyme-responsive imidazoquinoline TLR7/8 agonist prodrug vesicles. Journal of the American Chemical Society 142, 12133-12139 (2020)
8. Liang C, Bai X, Qi C, Sun Q, Han X, Lan T, Zhang H, Zheng X, Liang R, Jiao J, Zheng Z, Fang J, Lei P, Wang Y, Möckel D, Metselaar JM, Storm G, Hennink WE, Kiessling F, Wei H, Lammers T*, Shi Y*, Wei B*. Π electron-stabilized polymeric micelles potentiate docetaxel therapy in advanced-stage gastrointestinal cancer. Biomaterials 266, 120432 (2021)
9. Llop J*, Lammers T*. Nanoparticles for cancer diagnosis, radionuclide therapy and theranostics. ACS Nano 15, 16974, 16981 (2021)
10. Biancacci I, De Lorenzi F, Theek B, Bai X, May JN, Consolino L, Baues M, Moeckel D, Gremse F, von Stillfried S, El Shafei A, Benderski K, Azadkhah Shalmani A, Wang A, Momoh J, Peña Q, Buhl EM, Buyel J, Hennink W, Kiessling F, Metselaar J, Shi Y*, Lammers T*. Monitoring EPR effect dynamics during nanotaxane treatment with theranostic polymeric micelles. Adv Sci e2103745 (2022)

Publications