Person

PD Dr. rer. nat.

Wiltrud Lederle

Gruppenleiterin/ Biological Mechanisms

Nicht verfügbar Urheberrecht: Laiyin Yin
Lehrstuhl für Experimentelle Molekulare Bildgebung

Adresse

Gebäude: CBMS

Raum: 101

Forckenbeckstr. 55

52074 Aachen

Kontakt

WorkPhone
Telefon: +49 241 80 85906
 

Wiltrud Lederle arbeitete als Doktorandin am Deutschen Krebsforschungszentrum (DKFZ) in Heidelberg und promovierte an der Universität Hohenheim. Von 2003 bis 2008 war sie als wissenschaftliche Mitarbeiterin (Post-Doc) in verschiedenen Abteilungen des Deutschen Krebsforschungszentrums tätig. 2008 wechselte sie ans Institut für Experimentelle Molekulare Bildgebung der RTWH Aachen. Sie leitet die Arbeitsgruppe „Tumorprogression und Metastasierung“ und habilitierte sich 2019 an der Medizinischen Fakultät der RWTH Aachen. Ihre Forschung wird unter anderem von der DFG, dem BMBF und durch Industriekooperationen gefördert. Die Arbeitsgruppe untersucht als Hauptschwerpunkt den Einfluss der Mikroumgebung auf die Tumorprogression. Hierfür werden mit innovativen Bildgebungsverfahren die Tumorangiogenese, Immunantwort und Stroma-Aktivierung während der Tumorprogression untersucht und die Wirkmechanismen neuer therapeutischer Ansätze erforscht. Weitere Forschungsaktivitäten dienen der Untersuchung des stromalen Umbaus bei der Geweberegeneration und Entzündungsprozessen mit nichtinvasiver Bildgebung.

 

Publikationen

Titel Autor(en)
Lipid-encapsulated siRNA for hepatocyte-directed treatment of advanced liver disease
Fachzeitschriftenartikel (2020)
Woitok, Marius Maximilian
Zoubek, Miguel Eugenio
Doleschel, Dennis
Bartneck, Matthias
Mohamed, Mohamed Ramadan
Kießling, Fabian
Lederle, Wiltrud
Trautwein, Christian
Cubero, Francisco Javier
Optimizing the Geometry of Photoacoustically Active Gold Nanoparticles for Biomedical Imaging
Fachzeitschriftenartikel (2020)
Garcia-Álvarez, Rafaela
Chen, Lisa
Nedilko, Alexander
Sánchez-Iglesias, Ana
Rix, Anne
Lederle, Wiltrud
Pathak, Vertika
Lammers, Twan
Von Plessen, Geero
Kostarelos, Kostas
Liz-Marzan, Luis M.
Kuehne, Alexander J. C. (Corresponding author)
Chigrin, Dmitry N. (Corresponding author)
Assessment of Chemotherapy-Induced Organ Damage with Ga-68 Labeled Duramycin
Fachzeitschriftenartikel (2019)
Rix, Anne
Drude, Natascha Ingrid
Mrugalla, Anna
Baskaya, Ferhan
Pak, Koon Yan
Gray, Brian
Kaiser, Hans-Jürgen
Tolba, René Hany
Fiegle, Eva
Lederle, Wiltrud
Mottaghy, Felix Manuel
Kiessling, Fabian
Non-invasive Imaging and Modeling of Liver Regeneration After Partial Hepatectomy
Fachzeitschriftenartikel (2019)
Zafarnia, Sara
Mrugalla, Anna
Rix, Anne
Doleschel, Dennis
Gremse, Felix
Wolf, Stephanie D.
Buyel, Johannes Felix
Albrecht, Ute
Bode, Johannes G.
Kießling, Fabian
Lederle, Wiltrud (Corresponding author)
Hepatocyte-specific role of c-Jun N-terminal kinase 2 for disease progression and therapy in chronic liver disease
Abstract, Beitrag zu einem Tagungsband, Fachzeitschriftenartikel (2019)
Woitok, Marius Maximilian (Corresponding author)
Zoubek, Miguel Eugenio
Doleschel, Dennis
Kießling, Fabian
Lederle, Wiltrud
Trautwein, Christian
Cubero, Francisco Javier
Untersuchung der Rolle der Mikroumgebung bei der Tumorprogression mit nicht-invasiver Bildgebung
Habilitationsschrift (2019)
Lederle, Wiltrud
A water-soluble PEGylated RGD-functionalized bisbithiophenyl diketopyrrolopyrrole as a photoacoustic sonophore
Fachzeitschriftenartikel (2018)
Repenko, Tatjana
Rix, Anne
Haehnle, Bastian
Lederle, Wiltrud
De Laporte, Laura
Kuehne, Alexander J. C. (Corresponding author)
Advanced Ultrasound Technologies for Diagnosis and Therapy
Fachzeitschriftenartikel (2018)
Rix, Anne
Lederle, Wiltrud
Theek, Benjamin
Lammers, Twan
Moonen, Chrit
Schmitz, Georg
Kießling, Fabian (Corresponding author)
Strong Photoacoustic Signal Enhancement by Coating Gold Nanoparticles with Melanin for Biomedical Imaging
Fachzeitschriftenartikel (2017)
Repenko, Tatjana
Rix, Anne
Nedilko, Alexander
Rose, Jonas
Hermann, Alina
Vinokur, Rostislav
Moli, Sheila
Cao-Milàn, Roberto
Mayer, Martin
von Plessen, Gero
Fery, Andreas
De Laporte, Laura
Lederle, Wiltrud
Chigrin, Dmitry N. (Corresponding author)
Kuehne, Alexander J. C. (Corresponding author)
Hepatocyte nanodelivery using siRNA c-Jun N-terminal Kinase-2 (siJnk2) for the treatment of chronic liver disease
Abstract, Beitrag zu einem Tagungsband, Fachzeitschriftenartikel (2017)
Woitok, Marius M. (Corresponding author)
Doleschel, Dennis
Zoubek, Miguel Eugenio
Kießling, Fabian
Lederle, Wiltrud
Trautwein, Christian
Cubero, F. J.
Bio-degradable highly fluorescent conjugated polymer nanoparticles for bio-medical imaging applications
Fachzeitschriftenartikel (2017)
Repenko, Tatjana
Rix, Anne
Ludwanowski, Simon
Go, Dennis
Kießling, Fabian
Lederle, Wiltrud (Corresponding author)
Kühne, Alexander J. C. (Corresponding author)
Balancing Passive and Active Targeting to Different Tumor Compartments Using Riboflavin-Functionalized Polymeric Nanocarriers
Fachzeitschriftenartikel (2017)
Tsvetkova, Yoanna (Corresponding author)
Beztsinna, Nataliia
Baues, Maike
Klein, Dionne
Rix, Anne
Golombek, Susanne K.
Al Rawashdeh, Wa'el
Gremse, Felix
Barz, Matthias
Koynov, Kaloian
Banala, Srinivas
Lederle, Wiltrud
Lammers, Twan
Kiessling, Fabian
Nilotinib Enhances Tumor Angiogenesis and Counteracts VEGFR2 Blockade in an Orthotopic Breast Cancer Xenograft Model with Desmoplastic Response
Fachzeitschriftenartikel (2017)
Zafarnia, Sara
Bzyl-Ibach, Jessica
Spivak, Igor
Li, Yongping
Koletnik, Susanne
Doleschel, Dennis
Rix, Anne
Pochon, Sibylle
Tardy, Isabelle
Koyadan, Seena
van Zandvoort, Marc
Palmowski, Moritz
Kiessling, Fabian
Lederle, Wiltrud (Corresponding author)
Inducible Knockdown of c-Jun N-terminal Kinase-2 (Jnk2) in hepatocytes has a stage dependent effect on disease progression
Abstract, Beitrag zu einem Tagungsband, Fachzeitschriftenartikel (2017)
Woitok, Marius M.
Doleschel, Dennis
Zoubek, Miguel Eugenio
Kießling, Fabian
Lederle, Wiltrud
Trautwein, Christian
Cubero, Francisco Javier
In situ validation of VEGFR-2 and αvß3 integrin as targets for breast lesion characterization
Fachzeitschriftenartikel (2016)
Ehling, Josef Ludger Anton
Misiewicz, Matthias
von Stillfried, Saskia
Möckel, Diana
Bzyl, Jessica
Pochon, Sibylle
Lederle, Wiltrud
Knüchel-Clarke, Ruth
Lammers, Twan
Palmowski, Moritz
Kießling, Fabian (Corresponding author)
Erratum to: In situ validation of VEGFR-2 and αvß3 integrin as targets for breast lesion characterization
Fachzeitschriftenartikel (2016)
Ehling, Josef Ludger Anton
Misiewicz, Matthias
von Stillfried, Saskia
Möckel, Diana
Bzyl, Jessica
Pochon, Sibylle
Lederle, Wiltrud
Knüchel-Clarke, Ruth
Lammers, Twan
Palmowski, Moritz
Kießling, Fabian (Corresponding author)
Low-Dose Molecular Ultrasound Imaging with E-Selectin-Targeted PBCA Microbubbles
Fachzeitschriftenartikel (2015)
Spivak, Igor
Rix, Anne
Schmitz, Georg
Fokong, Stanley
Iranzo, Olga
Lederle, Wiltrud
Kießling, Fabian (Corresponding author)
Squamous Cell Carcinoma Xenografts: Use of VEGFR2-targeted Microbubbles for Combined Functional and Molecular US to Monitor Antiangiogenic Therapy Effects
Fachzeitschriftenartikel (2015)
Baetke, Sarah C.
Rix, Anne
Tranquart, François
Schneider, Richard
Lammers, Twan
Kießling, Fabian (Corresponding author)
Lederle, Wiltrud
Hybrid µCT-FMT imaging and image analysis
Fachzeitschriftenartikel (2015)
Gremse, Felix
Doleschel, Dennis
Zafarnia, Sara
Babler, Anne
Jahnen-Dechent, Willi
Lammers, Twan
Lederle, Wiltrud
Kießling, Fabian (Corresponding author)
Erythropoietin Improves the Accumulation and Therapeutic Effects of Carboplatin by Enhancing Tumor Vascularization and Perfusion
Fachzeitschriftenartikel (2015)
Doleschel, Dennis
Rix, Anne
Arns, Susanne
Palmowski, Karin
Gremse, Felix
Merkle, Ruth
Salopiata, Florian
Klingmüller, Ursula
Jarsch, Michael
Kießling, Fabian (Corresponding author)
Lederle, Wiltrud (Corresponding author)
RGD-decorated conjugated polymer particles as fluorescent biomedical probes prepared by Sonogashira dispersion polymerization
Fachzeitschriftenartikel (2015)
Anwar, Naveed
Rix, Anne
Lederle, Wiltrud
Kühne, Alexander J. C. (Corresponding author)
Bioactive Gyroid Scaffolds Formed by Sacrificial Templating of Nanocellulose and Nanochitin Hydrogels as Instructive Platforms for Biomimetic Tissue Engineering
Fachzeitschriftenartikel (2015)
Torres-Rendon, Jose Guillermo
Femmer, Tim
De Laporte, Laura
Tigges, Thomas
Rahimi, Khosrow
Gremse, Felix
Zafarnia, Sara
Lederle, Wiltrud
Ifuku, Shinsuke
Wessling, Matthias
Hardy, John G. (Corresponding author)
Walther, Andreas (Corresponding author)
Differential contrast of gold nanorods in dual-band OCT using spectral multiplexing
Fachzeitschriftenartikel (2015)
Al Rawashdeh, Wa'el
Weyand, Thomas
Kray, Stefan
Lenz, Markus
Buchkremer, Anne
Spöler, Felix
Simon, Ulrich
Möller, Martin
Kiessling, Fabian
Lederle, Wiltrud (Corresponding author)
In-vivo detection of the erythropoietin receptor in tumours using positron emission tomography
Fachzeitschriftenartikel (2015)
Fuge, Felix
Doleschel, Dennis
Rix, Anne
Gremse, Felix
Wessner, Axel
Winz, Oliver
Mottaghy, Felix Manuel
Lederle, Wiltrud
Kiessling, Fabian (Corresponding author)
Influence of Repetitive Contrast Agent Injections on Functional and Molecular Ultrasound Measurements
Fachzeitschriftenartikel (2014)
Rix, Anne
Palmowski, Moritz
Gremse, Felix
Palmowski, Karin
Lederle, Wiltrud
Kießling, Fabian
Bzyl, Jessica
Absorption Reconstruction Improves Biodistribution Assessment of Fluorescent Nanoprobes Using Hybrid Fluorescence-mediated Tomography
Fachzeitschriftenartikel (2014)
Gremse, Felix (Corresponding author)
Theek, Benjamin
Kunjachan, Sijumon
Lederle, Wiltrud
Pardo, Alessa
Barth, Stefan
Lammers, Twan
Naumann, Uwe
Kießling, Fabian
Recent advances in molecular, multimodal and theranostic ultrasound imaging
Buchbeitrag, Fachzeitschriftenartikel (2014)
Kießling, Fabian (Corresponding author)
Fokong, Stanley
Bzyl, Jessica
Lederle, Wiltrud
Palmowski, Moritz
Lammers, Twan
Optical Tomography of MMP Activity Allows a Sensitive Noninvasive Characterization of the Invasiveness and Angiogenesis of SCC Xenografts
Fachzeitschriftenartikel (2014)
Al Rawashdeh, Wa'el
Arns, Susanne
Gremse, Felix
Ehling, Josef Ludger Anton
Knüchel-Clarke, Ruth
Kray, Stefan
Spöler, Felix
Kießling, Fabian
Lederle, Wiltrud (Corresponding author)
Passive versus Active Tumor Targeting Using RGD- and NGR-Modified Polymeric Nanomedicines
Fachzeitschriftenartikel (2014)
Kunjachan, Sijumon
Pola, Robert
Gremse, Felix
Theek, Benjamin
Ehling, Josef Ludger Anton
Möckel, Diana
Hermanns-Sachweh, Benita
Pechar, Michal
Ulbrich, Karel
Hennink, Wim E.
Storm, Gert
Lederle, Wiltrud
Kießling, Fabian
Lammers, Twan
Micro-CT Imaging of Tumor Angiogenesis Quantitative Measures Describing Micromorphology and Vascularization
Fachzeitschriftenartikel (2014)
Ehling, Josef Ludger Anton
Theek, Benjamin
Gremse, Felix
Baetke, Sarah C.
Möckel, Diana
Maynard, Juliana
Ricketts, Sally-Ann
Grüll, Holger
Neeman, Michal
Knüchel-Clarke, Ruth
Lederle, Wiltrud
Kießling, Fabian
Lammers, Twan
A low molecular weight zinc2+-dipicolylamine-based probe detects apoptosis during tumour treatment better than an annexin V-based probe
Fachzeitschriftenartikel (2014)
Palmowski, Karin
Rix, Anne
Lederle, Wiltrud
Behrendt, Florian F.
Mottaghy, Felix Manuel
Gray, Brian D.
Pak, Koon Y.
Palmowski, Moritz
Kießling, Fabian
Ultrasound molecular imaging of E-selectin in tumor vessels using poly n-butyl cyanoacrylate microbubbles covalently coupled to a short targeting peptide
Fachzeitschriftenartikel (2013)
Fokong, Stanley
Fragoso, Ana
Rix, Anne
Curaj, Adelina
Wu, Zhuojun
Lederle, Wiltrud
Iranzo, Olga
Gätjens, Jessica
Kießling, Fabian
Palmowski, Moritz
Regorafenib Inhibits Growth, Angiogenesis, and Metastasis in a Highly Aggressive, Orthotopic Colon Cancer Model
Fachzeitschriftenartikel (2013)
Abou-Elkacem, Lotfi
Arns, Susanne
Brix, Gunnar
Gremse, Felix
Zopf, Dieter
Kießling, Fabian
Lederle, Wiltrud
Phase Shift Variance Imaging-A New Technique for Destructive Microbubble Imaging
Fachzeitschriftenartikel (2013)
Siepmann, Monica
Fokong, Stanley
Mienkina, Martin P.
Novak, Mara
Lederle, Wiltrud
Kießling, Fabian
Gätjens, Jessica
Schmitz, Georg
Liver Dysplasia : US Molecular Imaging with Targeted Contrast Agent Enables Early Assessment
Fachzeitschriftenartikel (2013)
Grouls, Christoph Franz Hubert
Hatting, Maximillian
Rix, Anne
Pochon, Sibylle
Lederle, Wiltrud
Tardy, Isabelle
Kuhl, Christiane
Trautwein, Christian
Kießling, Fabian
Palmowski, Moritz
The high angiogenic activity in very early breast cancer enables reliable imaging with VEGFR2-targeted microbubbles (BR55)
Fachzeitschriftenartikel (2013)
Bzyl, Jessica
Palmowski, Moritz
Rix, Anne
Arns, Susanne
Hyvelin, Jean-Marc
Pochon, Sibylle
Ehling, Josef Ludger Anton
Schrading, Simone
Kießling, Fabian
Lederle, Wiltrud
Cell type specific interleukin-6 induced responses in tumor keratinocytes and stromal fibroblasts are essential for invasive growth
Fachzeitschriftenartikel (2012)
Depner, Sofia
Lederle, Wiltrud
Gutschalk, Claudia M.
Linde, Nina
Zajonz, Alexandra
Mueller, Margareta M.
Molecular and functional ultrasound imaging of breast tumors
Abstract, Beitrag zu einem Tagungsband, Fachzeitschriftenartikel (2012)
Bzyl, Jessica
Lederle, Wiltrud
Palmowski, Moritz
Kießling, Fabian
Riboflavin carrier protein-targeted fluorescent USPIO for the assessment of vascular metabolism in tumors
Fachzeitschriftenartikel (2012)
Jayapaul, Jabadurai
Arns, Susanne
Lederle, Wiltrud
Lammers, Twan
Comba, Peter
Gätjens, Jessica
Kießling, Fabian
High accuracy of mesoscopic epi-fluorescence tomography for non-invasive quantitative volume determination of fluorescent protein-expressing tumours in mice
Fachzeitschriftenartikel (2012)
Abou-Elkacem, Lotfi
Björn, Saskia
Doleschel, Dennis
Ntziachristos, Vasilis
Schulz, Ralf
Hoffman, Robert M.
Kießling, Fabian
Lederle, Wiltrud
Vascular endothelial growth factor-induced skin carcinogenesis depends on recruitment and alternative activation of macrophages
Fachzeitschriftenartikel (2012)
Linde, Nina
Lederle, Wiltrud
Depner, Sofia
van Rooijen, Nico
Gutschalk, Claudia M.
Mueller, Margareta M.
Imaging in the age of molecular medicine: monitoring of anti-angiogenic treatments
Fachzeitschriftenartikel (2012)
Lederle, Wiltrud
Palmowski, Moritz
Kießling, Fabian
Ultrasound microbubbles for molecular diagnosis, therapy, and theranostics
Fachzeitschriftenartikel (2012)
Kießling, Fabian
Fokong, Stanley
Koczera, Patrick
Lederle, Wiltrud
Lammers, Twan
Targeted Near-Infrared Imaging of the Erythropoietin Receptor in Human Lung Cancer Xenografts
Fachzeitschriftenartikel (2012)
Doleschel, Dennis
Mundigl, Olaf
Wessner, Axel
Gremse, Felix
Bachmann, Julie
Rodriguez, Agustin
Klingmüller, Ursula
Jarsch, Michael
Kießling, Fabian
Lederle, Wiltrud
Comparison of μCT, MRI and Optical Reflectance Imaging for Assessing the Growth of GFP/RFP-expressing Tumors
Fachzeitschriftenartikel (2011)
Abou-Elkacem, Lotfi
Gremse, Felix
Barth, Stefan
Hoffman, Robert M.
Kießling, Fabian
Lederle, Wiltrud
IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines
Fachzeitschriftenartikel (2011)
Lederle, Wiltrud
Depner, Sofia
Schnur, Sabine
Obermueller, Eva
Catone, Nicola
Just, Alexandra
Fusenig, Norbert E.
Mueller, Margareta M.
Evaluation of high frequency ultrasound methods and contrast agents for characterising tumor response to anti-angiogenic treatment
Fachzeitschriftenartikel (2011)
Rix, Anne
Lederle, Wiltrud
Siepmann, Monica
Fokong, Stanley
Behrendt, Florian F.
Bzyl, Jessica
Grouls, Christoph Franz Hubert
Kießling, Fabian
Palmowski, Moritz
Failure of annexin-based apoptosis imaging in the assessment of antiangiogenic therapy effects
Fachzeitschriftenartikel (2011)
Lederle, Wiltrud (Corresponding author)
Arns, Susanne
Rix, Anne
Gremse, Felix
Doleschel, Dennis
Schmaljohann, Jörn
Mottaghy, Felix Manuel
Kießling, Fabian
Palmowski, Moritz
Molecular and functional ultrasound imaging in differently aggressive breast cancer xenografts using two novel ultrasound contrast agents (BR55 and BR38)
Fachzeitschriftenartikel (2011)
Bzyl, Jessica
Lederle, Wiltrud
Rix, Anne
Grouls, Christoph Franz Hubert
Tardy, Isabelle
Pochon, Sibylle
Siepmann, Monica
Penzkofer, Tobias
Schneider, Michel
Kießling, Fabian
Palmowski, Moritz
FMN-coated fluorescent iron oxide nanoparticles for RCP-mediated targeting and labeling of metabolically active cancer and endothelial cells
Fachzeitschriftenartikel (2011)
Jayapaul, Jabadurai
Hodenius, Michael
Arns, Susanne
Lederle, Wiltrud
Lammers, Twan
Comba, Peter
Kießling, Fabian
Gätjens, Jessica
Early Detection of Systems Response : Molecular and Functional Imaging of Angiogenesis
Buchbeitrag, Beitrag zu einem Tagungsband (2010)
Kießling, Fabian
Lederle, Wiltrud
MMP inhibition blocks fibroblast-dependent skin cancer invasion, reduces vascularization and alters VEGF-A and PDGF-BB expression
Fachzeitschriftenartikel (2010)
Woenne, Eva C.
Lederle, Wiltrud
Zwick, Stefan
Palmowski, Moritz
Krell, Hans
Semmler, Wolfhard
Mueller, Margareta M.
Kießling, Fabian
MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma
Fachzeitschriftenartikel (2010)
Lederle, Wiltrud
Hartenstein, Bettina
Meides, Alice
Kunzelmann, Heike
Werb, Zena
Angel, Peter
Mueller, Margareta M.
Platelet-derived growth factor-B normalizes micromorphology and vessel function in vascular endothelial growth factor-A-induced squamous cell carcinomas
Fachzeitschriftenartikel (2010)
Lederle, Wiltrud
Linde, Nina
Heusel, Julia
Bzyl, Jessica
Woenne, Eva C.
Zwick, Stefan
Skobe, Mihaela
Kießling, Fabian
Fusenig, Norbert E.
Mueller, Margareta M.
Molecular ultrasound imaging: Principles and potential application in diagnosis and therapy monitoring of breast cancer
Beitrag zu einem Tagungsband, Fachzeitschriftenartikel (2009)
Palmowski, Moritz
Lederle, Wiltrud
Bzyl, Jessica
Gätjens, Jessica
Kießling, Fabian
Comparison of conventional time-intensity curves vs. maximum intensity over time for post-processing of dynamic contrast-enhanced ultrasound
Fachzeitschriftenartikel (2009)
Palmowski, Moritz
Lederle, Wiltrud
Gätjens, Jessica
Socher, Michaela
Hauff, Peter
Bzyl, Jessica
Semmler, Wolfhard
Günther, Rolf W.
Kießling, Fabian
Assessment of vascular remodeling under antiangiogenic therapy using DCE-MRI and vessel size imaging
Fachzeitschriftenartikel (2009)
Zwick, Stefan
Strecker, Ralph
Kiselev, Valerji
Gall, Peter
Huppert, Jochen
Palmowski, Moritz
Lederle, Wiltrud
Woenne, Eva C.
Hengerer, Arne
Taupitz, Matthias
Semmler, Wolfhard
Kießling, Fabian
Distinct progression-associated expression of tumor and stromal MMPs in HaCaT skin SCCs correlates with onset of invasion
Fachzeitschriftenartikel (2009)
Vosseler, Silvia
Lederle, Wiltrud
Airola, Kristiina
Obermueller, Eva
Fusenig, Norbert E.
Mueller, Margareta M.
Initial tumor growth and tumor invasion are mediated by pdgf-bb and vegf-a activated fibroblasts
Abstract, Beitrag zu einem Tagungsband, Fachzeitschriftenartikel (2008)
Lederle, Wiltrud
Mueller, Margareta M.