Person

PD Dr. rer. nat., Privatdozentin

Wiltrud Lederle

Gruppenleiterin/ Biological Mechanisms

Wiltrud Lederle Copyright: © Private
Lehrstuhl für Experimentelle Molekulare Bildgebung

Address

Building: CBMS

Room: 101

Forckenbeckstr. 55

52074 Aachen

Contact

WorkPhone
Phone: +49 241 80 85906
 

Wiltrud Lederle worked as a PhD student at the German Cancer Research Center (DKFZ) in Heidelberg and obtained her PhD from the University of Hohenheim. From 2003 to 2008, she continued her work as a post-doctoral researcher in different departments at the German Cancer Research Center. In 2008, she joined the Institute for Experimental Molecular Imaging at RWTH Aachen University. She leads the research group “Tumor Progression and Metastasis” and obtained her habilitation at the Medical Faculty of RWTH Aachen University in 2019. Her research is funded by the DFG, BMBF and via industrial cooperations. Her research group mainly focusses on the influence of the microenvironment on tumor progression. Using innovative imaging technologies, the mechanisms of tumor angiogenesis, immune response and stromal activation are investigated during tumor progression and the effects of novel therapeutic approaches are explored. Further research activities include the investigation of stromal remodeling during tissue repair and organ inflammation by noninvasive imaging.

 

Publications

Title Author(s)
[Journal Article]
Lipid-encapsulated siRNA for hepatocyte-directed treatment of advanced liver disease
In: Cell death & disease, 11 (5), 343, 2020
[DOI: 10.1038/s41419-020-2571-4]
Woitok, Marius Maximilian
Zoubek, Miguel Eugenio
Doleschel, Dennis
Bartneck, Matthias
Mohamed, Mohamed Ramadan
Kießling, Fabian
Lederle, Wiltrud
Trautwein, Christian
Cubero, Francisco Javier
[Journal Article]
Optimizing the Geometry of Photoacoustically Active Gold Nanoparticles for Biomedical Imaging
In: ACS photonics, 7 (3), 646-652, 2020
[DOI: 10.1021/acsphotonics.9b01418]
Garcia-Álvarez, Rafaela
Chen, Lisa
Nedilko, Alexander
Sánchez-Iglesias, Ana
Rix, Anne
Lederle, Wiltrud
Pathak, Vertika
Lammers, Twan
Von Plessen, Geero
Kostarelos, Kostas
Liz-Marzan, Luis M.
Kuehne, Alexander J. C. (Corresponding author)
Chigrin, Dmitry N. (Corresponding author)
[Journal Article]
Assessment of Chemotherapy-Induced Organ Damage with Ga-68 Labeled Duramycin
In: Molecular imaging & biology : MIB, 22 (3), 623-633, 2019, 2020
[DOI: 10.1007/s11307-019-01417-3]
Rix, Anne
Drude, Natascha Ingrid
Mrugalla, Anna
Baskaya, Ferhan
Pak, Koon Yan
Gray, Brian
Kaiser, Hans-Jürgen
Tolba, René Hany
Fiegle, Eva
Lederle, Wiltrud
Mottaghy, Felix Manuel
Kiessling, Fabian
[Journal Article]
Non-invasive Imaging and Modeling of Liver Regeneration After Partial Hepatectomy
In: Frontiers in physiology, 10, 904, 2019
[DOI: 10.3389/fphys.2019.00904]
Zafarnia, Sara
Mrugalla, Anna
Rix, Anne
Doleschel, Dennis
Gremse, Felix
Wolf, Stephanie D.
Buyel, Johannes Felix
Albrecht, Ute
Bode, Johannes G.
Kießling, Fabian
Lederle, Wiltrud (Corresponding author)
[Abstract, Contribution to a conference proceedings, Journal Article]
Hepatocyte-specific role of c-Jun N-terminal kinase 2 for disease progression and therapy in chronic liver disease
In: Journal of hepatology, 70 (1, Supplement), FRI-507, 2019
[DOI: 10.1016/S0618-8278(19)31242-3]
Woitok, Marius Maximilian (Corresponding author)
Zoubek, Miguel Eugenio
Doleschel, Dennis
Kießling, Fabian
Lederle, Wiltrud
Trautwein, Christian
Cubero, Francisco Javier
[Habil / Postdoctoral Thesis (Non-german Habil)]
Untersuchung der Rolle der Mikroumgebung bei der Tumorprogression mit nicht-invasiver Bildgebung, 2019
Lederle, Wiltrud
[Journal Article]
A water-soluble PEGylated RGD-functionalized bisbithiophenyl diketopyrrolopyrrole as a photoacoustic sonophore
In: Photochemical & photobiological sciences, 17 (5), 617-621, 2018
[DOI: 10.1039/c8pp00069g]
Repenko, Tatjana
Rix, Anne
Haehnle, Bastian
Lederle, Wiltrud
De Laporte, Laura
Kuehne, Alexander J. C. (Corresponding author)
[Journal Article]
Advanced Ultrasound Technologies for Diagnosis and Therapy
In: Journal of nuclear medicine : JNM, 59 (5), 740-746, 2018
[DOI: 10.2967/jnumed.117.200030]
Rix, Anne
Lederle, Wiltrud
Theek, Benjamin
Lammers, Twan
Moonen, Chrit
Schmitz, Georg
Kießling, Fabian (Corresponding author)
[Journal Article]
Strong Photoacoustic Signal Enhancement by Coating Gold Nanoparticles with Melanin for Biomedical Imaging
In: Advanced functional materials, 28 (7), 1705607, 2017, 2018
[DOI: 10.1002/adfm.201705607]
Repenko, Tatjana
Rix, Anne
Nedilko, Alexander
Rose, Jonas
Hermann, Alina
Vinokur, Rostislav
Moli, Sheila
Cao-Milàn, Roberto
Mayer, Martin
von Plessen, Gero
Fery, Andreas
De Laporte, Laura
Lederle, Wiltrud
Chigrin, Dmitry N. (Corresponding author)
Kuehne, Alexander J. C. (Corresponding author)
[Abstract, Contribution to a conference proceedings, Journal Article]
Hepatocyte nanodelivery using siRNA c-Jun N-terminal Kinase-2 (siJnk2) for the treatment of chronic liver disease
In: Journal of hepatology, 66 (1, Supplement), FRI-112, 2017
[DOI: 10.1016/S0168-8278(17)31306-5]
Woitok, Marius M. (Corresponding author)
Doleschel, Dennis
Zoubek, Miguel Eugenio
Kießling, Fabian
Lederle, Wiltrud
Trautwein, Christian
Cubero, F. J.
[Journal Article]
Bio-degradable highly fluorescent conjugated polymer nanoparticles for bio-medical imaging applications
In: Nature Communications, 8 (1), 470, 2017
[DOI: 10.1038/s41467-017-00545-0]
Repenko, Tatjana
Rix, Anne
Ludwanowski, Simon
Go, Dennis
Kießling, Fabian
Lederle, Wiltrud (Corresponding author)
Kühne, Alexander J. C. (Corresponding author)
[Journal Article]
Balancing Passive and Active Targeting to Different Tumor Compartments Using Riboflavin-Functionalized Polymeric Nanocarriers
In: Nano letters, 17 (8), 4665-4674, 2017
[DOI: 10.1021/acs.nanolett.7b01171]
Tsvetkova, Yoanna (Corresponding author)
Beztsinna, Nataliia
Baues, Maike
Klein, Dionne
Rix, Anne
Golombek, Susanne K.
Al Rawashdeh, Wa'el
Gremse, Felix
Barz, Matthias
Koynov, Kaloian
Banala, Srinivas
Lederle, Wiltrud
Lammers, Twan
Kiessling, Fabian
[Journal Article]
Nilotinib Enhances Tumor Angiogenesis and Counteracts VEGFR2 Blockade in an Orthotopic Breast Cancer Xenograft Model with Desmoplastic Response
In: Neoplasia, 19 (11), 896-907, 2017
[DOI: 10.1016/j.neo.2017.08.009]
Zafarnia, Sara
Bzyl-Ibach, Jessica
Spivak, Igor
Li, Yongping
Koletnik, Susanne
Doleschel, Dennis
Rix, Anne
Pochon, Sibylle
Tardy, Isabelle
Koyadan, Seena
van Zandvoort, Marc
Palmowski, Moritz
Kiessling, Fabian
Lederle, Wiltrud (Corresponding author)
[Abstract, Contribution to a conference proceedings, Journal Article]
Inducible Knockdown of c-Jun N-terminal Kinase-2 (Jnk2) in hepatocytes has a stage dependent effect on disease progression
In: Hepatology, 66 (S1), 698, 2017
Woitok, Marius M.
Doleschel, Dennis
Zoubek, Miguel Eugenio
Kießling, Fabian
Lederle, Wiltrud
Trautwein, Christian
Cubero, Francisco Javier
[Journal Article]
In situ validation of VEGFR-2 and αvß3 integrin as targets for breast lesion characterization
In: Angiogenesis, 19 (2), 245-254, 2016
[DOI: 10.1007/s10456-016-9499-4]
Ehling, Josef Ludger Anton
Misiewicz, Matthias
von Stillfried, Saskia
Möckel, Diana
Bzyl, Jessica
Pochon, Sibylle
Lederle, Wiltrud
Knüchel-Clarke, Ruth
Lammers, Twan
Palmowski, Moritz
Kießling, Fabian (Corresponding author)
[Journal Article]
Erratum to: In situ validation of VEGFR-2 and αvß3 integrin as targets for breast lesion characterization
In: Angiogenesis, 19 (3), 449-449, 2016
[DOI: 10.1007/s10456-016-9507-8]
Ehling, Josef Ludger Anton
Misiewicz, Matthias
von Stillfried, Saskia
Möckel, Diana
Bzyl, Jessica
Pochon, Sibylle
Lederle, Wiltrud
Knüchel-Clarke, Ruth
Lammers, Twan
Palmowski, Moritz
Kießling, Fabian (Corresponding author)
[Journal Article]
Low-Dose Molecular Ultrasound Imaging with E-Selectin-Targeted PBCA Microbubbles
In: Molecular imaging & biology : MIB, 18 (2), 180-190, 2015, 2016
[DOI: 10.1007/s11307-015-0894-9]
Spivak, Igor
Rix, Anne
Schmitz, Georg
Fokong, Stanley
Iranzo, Olga
Lederle, Wiltrud
Kießling, Fabian (Corresponding author)
[Journal Article]
Squamous Cell Carcinoma Xenografts: Use of VEGFR2-targeted Microbubbles for Combined Functional and Molecular US to Monitor Antiangiogenic Therapy Effects
In: Radiology, 278 (2), 430-440, 2015, 2016
[DOI: 10.1148/radiol.2015142899]
Baetke, Sarah C.
Rix, Anne
Tranquart, François
Schneider, Richard
Lammers, Twan
Kießling, Fabian (Corresponding author)
Lederle, Wiltrud
[Journal Article]
Hybrid µCT-FMT imaging and image analysis
In: Journal of visualized experiments (100), e52770, 2015
[DOI: 10.3791/52770]
Gremse, Felix
Doleschel, Dennis
Zafarnia, Sara
Babler, Anne
Jahnen-Dechent, Willi
Lammers, Twan
Lederle, Wiltrud
Kießling, Fabian (Corresponding author)
[Journal Article]
Erythropoietin Improves the Accumulation and Therapeutic Effects of Carboplatin by Enhancing Tumor Vascularization and Perfusion
In: Theranostics, 5 (8), 905-918, 2015
[DOI: 10.7150/thno.11304]
Doleschel, Dennis
Rix, Anne
Arns, Susanne
Palmowski, Karin
Gremse, Felix
Merkle, Ruth
Salopiata, Florian
Klingmüller, Ursula
Jarsch, Michael
Kießling, Fabian (Corresponding author)
Lederle, Wiltrud (Corresponding author)
[Journal Article]
RGD-decorated conjugated polymer particles as fluorescent biomedical probes prepared by Sonogashira dispersion polymerization
In: Chemical communications, 51 (45), 9358-9361, 2015, 2017
[DOI: 10.1039/C4CC10092A]
Anwar, Naveed
Rix, Anne
Lederle, Wiltrud
Kühne, Alexander J. C. (Corresponding author)
[Journal Article]
Bioactive Gyroid Scaffolds Formed by Sacrificial Templating of Nanocellulose and Nanochitin Hydrogels as Instructive Platforms for Biomimetic Tissue Engineering
In: Advanced materials, 27 (19), 2989-2995, 2015
[DOI: 10.1002/adma.201405873]
Torres-Rendon, Jose Guillermo
Femmer, Tim
De Laporte, Laura
Tigges, Thomas
Rahimi, Khosrow
Gremse, Felix
Zafarnia, Sara
Lederle, Wiltrud
Ifuku, Shinsuke
Wessling, Matthias
Hardy, John G. (Corresponding author)
Walther, Andreas (Corresponding author)
[Journal Article]
Differential contrast of gold nanorods in dual-band OCT using spectral multiplexing
In: Journal of nanoparticle research, 17 (3), 138, 2015
[DOI: 10.1007/s11051-015-2949-x]
Al Rawashdeh, Wa'el
Weyand, Thomas
Kray, Stefan
Lenz, Markus
Buchkremer, Anne
Spöler, Felix
Simon, Ulrich
Möller, Martin
Kiessling, Fabian
Lederle, Wiltrud (Corresponding author)
[Journal Article]
In-vivo detection of the erythropoietin receptor in tumours using positron emission tomography
In: European radiology, 25 (2), 472-479, 2015
[DOI: 10.1007/s00330-014-3413-5]
Fuge, Felix
Doleschel, Dennis
Rix, Anne
Gremse, Felix
Wessner, Axel
Winz, Oliver
Mottaghy, Felix Manuel
Lederle, Wiltrud
Kiessling, Fabian (Corresponding author)
[Journal Article]
Influence of Repetitive Contrast Agent Injections on Functional and Molecular Ultrasound Measurements
In: Ultrasound in medicine and biology, 40 (10), 2468-2475, 2014
[DOI: 10.1016/j.ultrasmedbio.2014.04.010]
Rix, Anne
Palmowski, Moritz
Gremse, Felix
Palmowski, Karin
Lederle, Wiltrud
Kießling, Fabian (Corresponding author)
Bzyl, Jessica
[Journal Article]
Absorption Reconstruction Improves Biodistribution Assessment of Fluorescent Nanoprobes Using Hybrid Fluorescence-mediated Tomography
In: Theranostics, 4 (10), 960-971, 2014
[DOI: 10.7150/thno.9293]
Gremse, Felix (Corresponding author)
Theek, Benjamin
Kunjachan, Sijumon
Lederle, Wiltrud
Pardo, Alessa
Barth, Stefan
Lammers, Twan
Naumann, Uwe
Kießling, Fabian
[Contribution to a book, Journal Article]
Recent advances in molecular, multimodal and theranostic ultrasound imaging
In: Advanced drug delivery reviews, 72, 15-27, 2014
[DOI: 10.1016/j.addr.2013.11.013]
Kießling, Fabian (Corresponding author)
Fokong, Stanley
Bzyl, Jessica
Lederle, Wiltrud
Palmowski, Moritz
Lammers, Twan
[Journal Article]
Optical Tomography of MMP Activity Allows a Sensitive Noninvasive Characterization of the Invasiveness and Angiogenesis of SCC Xenografts
In: Neoplasia : an international journal for oncology research, 16 (3), 235-246, 2014
[DOI: 10.1016/j.neo.2014.03.005]
Al Rawashdeh, Wa'el
Arns, Susanne
Gremse, Felix
Ehling, Josef Ludger Anton
Knüchel-Clarke, Ruth
Kray, Stefan
Spöler, Felix
Kießling, Fabian
Lederle, Wiltrud (Corresponding author)
[Journal Article]
Passive versus Active Tumor Targeting Using RGD- and NGR-Modified Polymeric Nanomedicines
In: Nano letters, 14 (2), 972-981, 2014
[DOI: 10.1021/nl404391r]
Kunjachan, Sijumon
Pola, Robert
Gremse, Felix
Theek, Benjamin
Ehling, Josef Ludger Anton
Möckel, Diana
Hermanns-Sachweh, Benita
Pechar, Michal
Ulbrich, Karel
Hennink, Wim E.
Storm, Gert
Lederle, Wiltrud
Kießling, Fabian
Lammers, Twan
[Journal Article]
Micro-CT Imaging of Tumor Angiogenesis Quantitative Measures Describing Micromorphology and Vascularization
In: The American journal of pathology, 184 (2), 431-441, 2014
[DOI: 10.1016/j.ajpath.2013.10.014]
Ehling, Josef Ludger Anton
Theek, Benjamin
Gremse, Felix
Baetke, Sarah C.
Möckel, Diana
Maynard, Juliana
Ricketts, Sally-Ann
Grüll, Holger
Neeman, Michal
Knüchel-Clarke, Ruth
Lederle, Wiltrud
Kießling, Fabian
Lammers, Twan
[Journal Article]
A low molecular weight zinc2+-dipicolylamine-based probe detects apoptosis during tumour treatment better than an annexin V-based probe
In: European radiology, 24 (2), 363-370, 2014
[DOI: 10.1007/s00330-013-3014-8]
Palmowski, Karin
Rix, Anne
Lederle, Wiltrud
Behrendt, Florian F.
Mottaghy, Felix Manuel
Gray, Brian D.
Pak, Koon Y.
Palmowski, Moritz
Kießling, Fabian
[Journal Article]
Ultrasound molecular imaging of E-selectin in tumor vessels using poly n-butyl cyanoacrylate microbubbles covalently coupled to a short targeting peptide
In: Investigative radiology, 48 (12), 843-850, 2013
[DOI: 10.1097/RLI.0b013e31829d03ec]
Fokong, Stanley
Fragoso, Ana
Rix, Anne
Curaj, Adelina
Wu, Zhuojun
Lederle, Wiltrud
Iranzo, Olga
Gätjens, Jessica
Kießling, Fabian
Palmowski, Moritz
[Journal Article]
Regorafenib Inhibits Growth, Angiogenesis, and Metastasis in a Highly Aggressive, Orthotopic Colon Cancer Model
In: Molecular cancer therapeutics : MCT, 12 (7), 1322-1331, 2013
[DOI: 10.1158/1535-7163.MCT-12-1162]
Abou-Elkacem, Lotfi
Arns, Susanne
Brix, Gunnar
Gremse, Felix
Zopf, Dieter
Kießling, Fabian
Lederle, Wiltrud
[Journal Article]
Phase Shift Variance Imaging-A New Technique for Destructive Microbubble Imaging
In: IEEE transactions on ultrasonics, ferroelectrics, and frequency control : UFFC, 60 (5), 909-923, 2013
[DOI: 10.1109/TUFFC.2013.2648]
Siepmann, Monica
Fokong, Stanley
Mienkina, Martin P.
Novak, Mara
Lederle, Wiltrud
Kießling, Fabian
Gätjens, Jessica
Schmitz, Georg
[Journal Article]
Liver Dysplasia : US Molecular Imaging with Targeted Contrast Agent Enables Early Assessment
In: Radiology, 267 (2), 487-495, 2013
[DOI: 10.1148/radiol.13120220]
Grouls, Christoph Franz Hubert
Hatting, Maximillian
Rix, Anne
Pochon, Sibylle
Lederle, Wiltrud
Tardy, Isabelle
Kuhl, Christiane
Trautwein, Christian
Kießling, Fabian
Palmowski, Moritz
[Journal Article]
The high angiogenic activity in very early breast cancer enables reliable imaging with VEGFR2-targeted microbubbles (BR55)
In: European radiology, 23 (2), 468-475, 2013
[DOI: 10.1007/s00330-012-2594-z]
Bzyl, Jessica
Palmowski, Moritz
Rix, Anne
Arns, Susanne
Hyvelin, Jean-Marc
Pochon, Sibylle
Ehling, Josef Ludger Anton
Schrading, Simone
Kießling, Fabian
Lederle, Wiltrud
[Journal Article]
Cell type specific interleukin-6 induced responses in tumor keratinocytes and stromal fibroblasts are essential for invasive growth
In: International journal of cancer, 135 (3), 551-562, 2012, 2014
[DOI: 10.1002/ijc.27951]
Depner, Sofia
Lederle, Wiltrud
Gutschalk, Claudia M.
Linde, Nina
Zajonz, Alexandra
Mueller, Margareta M.
[Abstract, Contribution to a conference proceedings, Journal Article]
Molecular and functional ultrasound imaging of breast tumors
In: European journal of radiology : EJR, 81 (S1), S11-2, 2012
[DOI: 10.1016/S0720-048X(12)70005-0]
Bzyl, Jessica
Lederle, Wiltrud
Palmowski, Moritz
Kießling, Fabian
[Journal Article]
Riboflavin carrier protein-targeted fluorescent USPIO for the assessment of vascular metabolism in tumors
In: Biomaterials, 33 (34), 8822-8829, 2012
[DOI: 10.1016/j.biomaterials.2012.08.036]
Jayapaul, Jabadurai
Arns, Susanne
Lederle, Wiltrud
Lammers, Twan
Comba, Peter
Gätjens, Jessica
Kießling, Fabian
[Journal Article]
High accuracy of mesoscopic epi-fluorescence tomography for non-invasive quantitative volume determination of fluorescent protein-expressing tumours in mice
In: European radiology, 22 (9), 1955-1962, 2012
[DOI: 10.1007/s00330-012-2462-x]
Abou-Elkacem, Lotfi
Björn, Saskia
Doleschel, Dennis
Ntziachristos, Vasilis
Schulz, Ralf
Hoffman, Robert M.
Kießling, Fabian
Lederle, Wiltrud
[Journal Article]
Vascular endothelial growth factor-induced skin carcinogenesis depends on recruitment and alternative activation of macrophages
In: The journal of pathology, 227 (1), 17-28, 2012
[DOI: 10.1002/path.3989]
Linde, Nina
Lederle, Wiltrud
Depner, Sofia
van Rooijen, Nico
Gutschalk, Claudia M.
Mueller, Margareta M.
[Journal Article]
Imaging in the age of molecular medicine: monitoring of anti-angiogenic treatments
In: Current pharmaceutical biotechnology, 13 (4), 595-608, 2012
[DOI: 10.2174/138920112799436348]
Lederle, Wiltrud
Palmowski, Moritz
Kießling, Fabian
[Journal Article]
Ultrasound microbubbles for molecular diagnosis, therapy, and theranostics
In: Journal of nuclear medicine : JNM, 53 (3), 345-348, 2012
[DOI: 10.2967/jnumed.111.099754]
Kießling, Fabian
Fokong, Stanley
Koczera, Patrick
Lederle, Wiltrud
Lammers, Twan
[Journal Article]
Targeted Near-Infrared Imaging of the Erythropoietin Receptor in Human Lung Cancer Xenografts
In: Journal of nuclear medicine : JNM, 53 (2), 304-311, 2012
[DOI: 10.2967/jnumed.111.091124]
Doleschel, Dennis
Mundigl, Olaf
Wessner, Axel
Gremse, Felix
Bachmann, Julie
Rodriguez, Agustin
Klingmüller, Ursula
Jarsch, Michael
Kießling, Fabian
Lederle, Wiltrud
[Journal Article]
Comparison of μCT, MRI and Optical Reflectance Imaging for Assessing the Growth of GFP/RFP-expressing Tumors
In: Anticancer research, 31 (9), 2907-2913, 2011
Abou-Elkacem, Lotfi
Gremse, Felix
Barth, Stefan
Hoffman, Robert M.
Kießling, Fabian
Lederle, Wiltrud
[Journal Article]
IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines
In: International journal of cancer, 128 (12), 2803-2814, 2011
[DOI: 10.1002/ijc.25621]
Lederle, Wiltrud
Depner, Sofia
Schnur, Sabine
Obermueller, Eva
Catone, Nicola
Just, Alexandra
Fusenig, Norbert E.
Mueller, Margareta M.
[Journal Article]
Evaluation of high frequency ultrasound methods and contrast agents for characterising tumor response to anti-angiogenic treatment
In: European journal of radiology : EJR, 2011, 2011
[DOI: 10.1016/j.ejrad.2011.10.004]
Rix, Anne
Lederle, Wiltrud
Siepmann, Monica
Fokong, Stanley
Behrendt, Florian F.
Bzyl, Jessica
Grouls, Christoph Franz Hubert
Kießling, Fabian
Palmowski, Moritz
[Journal Article]
Failure of annexin-based apoptosis imaging in the assessment of antiangiogenic therapy effects
In: EJNMMI Research, 1 (1), 26, 2011
[DOI: 10.1186/2191-219X-1-26]
Lederle, Wiltrud (Corresponding author)
Arns, Susanne
Rix, Anne
Gremse, Felix
Doleschel, Dennis
Schmaljohann, Jörn
Mottaghy, Felix Manuel
Kießling, Fabian
Palmowski, Moritz
[Journal Article]
Molecular and functional ultrasound imaging in differently aggressive breast cancer xenografts using two novel ultrasound contrast agents (BR55 and BR38)
In: European radiology, 21 (9), 1988-1995, 2011
[DOI: 10.1007/s00330-011-2138-y]
Bzyl, Jessica
Lederle, Wiltrud
Rix, Anne
Grouls, Christoph Franz Hubert
Tardy, Isabelle
Pochon, Sibylle
Siepmann, Monica
Penzkofer, Tobias
Schneider, Michel
Kießling, Fabian
Palmowski, Moritz
[Journal Article]
FMN-coated fluorescent iron oxide nanoparticles for RCP-mediated targeting and labeling of metabolically active cancer and endothelial cells
In: Biomaterials, 32 (25), 5863-5871, 2011
[DOI: 10.1016/j.biomaterials.2011.04.056]
Jayapaul, Jabadurai
Hodenius, Michael
Arns, Susanne
Lederle, Wiltrud
Lammers, Twan
Comba, Peter
Kießling, Fabian
Gätjens, Jessica
[Contribution to a book, Contribution to a conference proceedings]
Early Detection of Systems Response : Molecular and Functional Imaging of Angiogenesis
In: From molecular to modular tumor therapy: tumors are reconstructible communicatively evolving systems / Albrecht Reichle (ed.), 385-403, 2010
[DOI: 10.1007/978-90-481-9531-2_20]
Kießling, Fabian
Lederle, Wiltrud
[Journal Article]
MMP inhibition blocks fibroblast-dependent skin cancer invasion, reduces vascularization and alters VEGF-A and PDGF-BB expression
In: Anticancer research, 30 (3), 703-711, 2010
Woenne, Eva C.
Lederle, Wiltrud
Zwick, Stefan
Palmowski, Moritz
Krell, Hans
Semmler, Wolfhard
Mueller, Margareta M.
Kießling, Fabian
[Journal Article]
MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma
In: Carcinogenesis, 31 (7), 1175-1184, 2010
[DOI: 10.1093/carcin/bgp248]
Lederle, Wiltrud
Hartenstein, Bettina
Meides, Alice
Kunzelmann, Heike
Werb, Zena
Angel, Peter
Mueller, Margareta M.
[Journal Article]
Platelet-derived growth factor-B normalizes micromorphology and vessel function in vascular endothelial growth factor-A-induced squamous cell carcinomas
In: The American journal of pathology, 176 (2), 981-994, 2010
[DOI: 10.2353/ajpath.2010.080998]
Lederle, Wiltrud
Linde, Nina
Heusel, Julia
Bzyl, Jessica
Woenne, Eva C.
Zwick, Stefan
Skobe, Mihaela
Kießling, Fabian
Fusenig, Norbert E.
Mueller, Margareta M.
[Contribution to a conference proceedings, Journal Article]
Molecular ultrasound imaging: Principles and potential application in diagnosis and therapy monitoring of breast cancer
In: European radiology, 19, S862-8, 2009
[DOI: 10.1007/s00330-009-1569-1]
Palmowski, Moritz
Lederle, Wiltrud
Bzyl, Jessica
Gätjens, Jessica
Kießling, Fabian
[Journal Article]
Comparison of conventional time-intensity curves vs. maximum intensity over time for post-processing of dynamic contrast-enhanced ultrasound
In: European journal of radiology : EJR, 2009, 2009
[DOI: 10.1016/j.ejrad.2009.10.030]
Palmowski, Moritz
Lederle, Wiltrud
Gätjens, Jessica
Socher, Michaela
Hauff, Peter
Bzyl, Jessica
Semmler, Wolfhard
Günther, Rolf W.
Kießling, Fabian
[Journal Article]
Assessment of vascular remodeling under antiangiogenic therapy using DCE-MRI and vessel size imaging
In: Journal of magnetic resonance imaging : JMRI, 29 (5), 1125-1133, 2009
[DOI: 10.1002/jmri.21710]
Zwick, Stefan
Strecker, Ralph
Kiselev, Valerji
Gall, Peter
Huppert, Jochen
Palmowski, Moritz
Lederle, Wiltrud
Woenne, Eva C.
Hengerer, Arne
Taupitz, Matthias
Semmler, Wolfhard
Kießling, Fabian
[Journal Article]
Distinct progression-associated expression of tumor and stromal MMPs in HaCaT skin SCCs correlates with onset of invasion
In: International journal of cancer, 125 (10), 2296-2306, 2009
[DOI: 10.1002/ijc.24589]
Vosseler, Silvia
Lederle, Wiltrud
Airola, Kristiina
Obermueller, Eva
Fusenig, Norbert E.
Mueller, Margareta M.
[Abstract, Contribution to a conference proceedings, Journal Article]
Initial tumor growth and tumor invasion are mediated by pdgf-bb and vegf-a activated fibroblasts
In: Anticancer research, 28 (5C), 389, 2008
Lederle, Wiltrud
Mueller, Margareta M.