Person

Dr.

Yang Shi

Gruppenleiter

Yang Shi Copyright: © Private
Lehrstuhl für Experimentelle Molekulare Bildgebung

Address

Building: CBMS

Room: 101

Forckenbeckstr. 55

52074 Aachen

Contact

WorkPhone
Phone: +49 241 80 85914
 

Dr. Shi founded and directs the research group “Polymer Therapeutics” at RWTH Aachen University Clinic. He currently leads projects from European Research Council (ERC Starting Grant) and German Research Foundation (DFG) as the Principal Investigator. He obtained a PhD degree from Utrecht University in 2014 on novel polymeric micelles for tumor-targeted drug delivery in the group of Wim Hennink. Shortly after PhD, he was appointed as Associate Professor at South China University of Technology and in 2016 as Group Leader at RWTH Aachen University Clinic. He has supervised 6 PhD and master students in Aachen. His research is recognized by several awards, e.g., Science Award (International Pharma Sciences Foundation/Rottendorf Stiftung), Theodore von Kármán Fellow, Rising Star (Symposium on Innovative Polymers for Controlled Delivery) and Merck Best On-Demand Talk Award (Controlled Release Society). Since 2021 he is an Associate Editor for the Journal of Nanobiotechnology. The main research topics of Dr. Shi’ group are:

  1. Clinical translation of polymeric micelles for combination chemo-immunotherapy. He previously developed and patented the Π-Π-stacking-stabilized polymeric micelles which have shown convincing efficacy and safety in several preclinical models. Currently, the micelles are in development for clinical translation with financial support from the German Federal Ministry of Education and Research (BMBF).

  1. Enzyme-sensitive prodrug vesicles for immunotherapy and vaccination. Dr. Shi’ group developed the first enzyme-sensitive prodrug vesicles based on amphiphilic conjugates of polymers and prodrug derivatives of small molecule immunostimulants. The vesicles are highly efficient in activating antigen-presenting cells and are currently being developed for immunotherapy and vaccination.

  1. Covalently self-assembled nanogels, microgel and hydrogels . His group recently established a novel covalent self-assembly strategy to construct highly tunable and multifunctional gel biomaterials at the nano- to macroscopic scale. These materials are used to deliver small molecule and macromolecular drugs, as well as to engineer tissues and organs.

Selected publications:

  1. Bai X, Sun Q, Guerzoni L, Wuttke S, Kiessling F, De Laporte L, Lammers T, Shi Y*. Controlled covalent self-assembly of a homopolymer for multiscale materials engineering. Adv Mater. 2022, In press. (IF=32.1)
  2. Shi Y*. Linking B cell metabolism to immune regulation: the neurotransmitter GABA. Signal Transduct. Target. Ther. 2022, 7, 260. (IF=38.1)
  3. Biancacci I, De Lorenzi F, Theek B, Bai X, May JN, Consolino L, Baues M, Moeckel D, Gremse F, von Stillfried S, El Shafei A, Benderski K, Azadkhah Shalmani A, Wang A, Momoh J, Peña Q, Buhl EM, Buyel J, Hennink W, Kiessling F, Metselaar J, Shi Y*, Lammers T*. Monitoring EPR effect dynamics during nanotaxane treatment with theranostic polymeric micelles. Adv Sci. 2022, e2103745 (IF=17.5)
  4. Liu D, Long M, Gao L, Chen Y, Li F, Shi Y*, Gu N*. Nanomedicines targeting respiratory injuries for pulmonary disease management. Adv Func Mater. 2022, 2112258 (IF=19.9)
  5. Roemhild K, Besse H, Wang B, Pena Q, Sun Q, Omata D, Ozbakir B, Bos C, Scheeren H, Storm G, Metselaar J, Yu H, Knüchel-Clarke R, Kiessling F, Moonen C, Deckers R*, Shi Y*, Lammers T*. Ultrasound-directed enzyme-prodrug therapy (UDEPT) using self-immolative doxorubicin derivatives. Theranostics. 2022, 12, 4791-4801. (IF=11.6)
  6. Shi Y*. PLAN B for immunotherapy: Promoting and leveraging anti-tumor B cell immunity. J Control Release. 2021, 339, 156-163. (IF=11.5)
  7. Liang C, Bai X, Qi C, Sun Q, Han X, Lan T, Zhang H, Zheng Z, Liang R, Jiao J, Zheng Z, Fang J, Lei P, Metselaar JM, Storm G, Hennink W, Kiessling F, Wei H*, Lammers T*, Shi Y*, Wei B*. Π electron-stabilized polymeric micelles potentiate docetaxel efficacy in advanced-stage gastrointestinal cancer. Biomaterials. 2021, 120432 (IF=10.3)
  8. Wang B, Van Herck S, Chen Y, Bai X, Zhong Z, Deswarte K, Lambrecht B, Sanders N, Scheere H, David S, Kiessling F, Lammers T*, De Geest B*, Shi Y*. Potent and prolonged innate immune activation by enzyme-responsive imidazoquinoline TLR7/8 agonist prodrug vesicles. JACS. 2020, 142, 12133 (IF=16.4)
  9. Shi Y*, Lammers T*. Combining nanomedicine and immunotherapy. Acc Chem Res. 2019, 52, 1543 (IF=24.5)
  10. Sun Q, Barz M, De Geest B, Diken M, Hennink W E, Kiessling F, Lammers T*, Shi Y*. Nanomedicine and macroscale materials in immuno-oncology. Che Soc Rev. 2019, 48, 351 (IF=60.6)
 

Publications

Title Author(s)
Linking B cell metabolism to immune regulation : the neurotransmitter GABA
Journal Article (2022)
Shi, Yang (Corresponding author)
Monitoring EPR Effect Dynamics during Nanotaxane Treatment with Theranostic Polymeric Micelles
Contribution to a book, Journal Article (2022)
Biancacci, Ilaria
De Lorenzi, Federica
Theek, Benjamin
Bai, Xiangyang
May, Jan-Niklas
Consolino, Lorena
Baues, Maike
Moeckel, Diana
Gremse, Felix
Stillfried, Saskia
El Shafei, Asmaa
Benderski, Karina
Azadkhah Shalmani, Armin
Wang, Alec
Momoh, Jeffrey
Peña, Quim
Buhl, Eva Miriam
Buyel, Johannes Felix
Hennink, Wim
Kießling, Fabian
Metselaar, Josbert
Shi, Yang (Corresponding author)
Lammers, Twan (Corresponding author)
Π electron-stabilized polymeric micelles potentiate docetaxel therapy in advanced-stage gastrointestinal cancer
Journal Article (2021)
Liang, Chenghua
Bai, Xiangyang
Qi, Cuiling
Sun, Qingxue
Han, Xiaoyan
Lan, Tianyun
Zhang, Haibo
Zheng, Xiaoming
Liang, Rongpu
Jiao, Ju
Zheng, Zongheng
Fang, Jiafeng
Lei, Purun
Wang, Yan
Möckel, Diana
Metselaar, Josbert M.
Storm, Gert
Hennink, Wim E.
Kiessling, Fabian
Wei, Hongbo (Corresponding author)
Lammers, Twan
Shi, Yang (Corresponding author)
Wei, Bo (Corresponding author)
Therapeutic and diagnostic targeting of fibrosis in metabolic, proliferative and viral disorders
Journal Article (2021)
Sofias, Alexandros Marios
De Lorenzi, Federica
Peña, Quim
Azadkhah Shalmani, Armin
Vucur, Mihael
Wang, Jiong-Wei
Kiessling, Fabian
Shi, Yang
Consolino, Lorena
Storm, Gert
Lammers, Twan
PLAN B for immunotherapy : Promoting and leveraging anti-tumor B cell immunity
Journal Article (2021)
Shi, Yang
From Design to Clinic: Engineered Nanobiomaterials for Immune Normalization Therapy of Cancer
Journal Article (2021)
Saeed, Madiha
Chen, Fangming
Ye, Jiayi
Shi, Yang
Lammers, Twan
De Geest, Bruno G.
Xu, Zhi Ping
Yu, Haijun
Optical imaging of the whole-body to cellular biodistribution of clinical-stage PEG-b-pHPMA-based core-crosslinked polymeric micelles
Contribution to a book, Journal Article (2020)
Biancacci, Ilaria
Sun, Qingxue
Möckel, Diana
Gremse, Felix
Rosenhain, Stefanie
Kiessling, Fabian
Bartneck, Matthias
Hu, Qizhi
Thewissen, Marielle
Storm, Gert
Hennink, Wim E.
Shi, Yang
Rijcken, Cristianne J. F. (Corresponding author)
Lammers, Twan (Corresponding author)
Sofias, Alexandros Marios (Corresponding author)
Systematic evaluation of design features enables efficient selection of ? electron-stabilized polymeric micelles
Journal Article (2020)
Sheybanifard, Maryam
Beztsinna, Nataliia
Bagheri, Mahsa
Buhl, Eva Miriam
Bresseleers, Jaleesa
Varela-Moreira, Aida
Shi, Yang
van Nostrum, Cornelus F.
van der Pluijm, Gabri
Storm, Gert
Hennink, Wim E.
Lammers, Twan
Metselaar, Josbert M. (Corresponding author)
The EPR effect and beyond: Strategies to improve tumor targeting and cancer nanomedicine treatment efficacy
Journal Article (2020)
Shi, Yang (Corresponding author)
van der Meel, Roy (Corresponding author)
Chen, Xiaoyuan (Corresponding author)
Lammers, Twan (Corresponding author)
Drug Loading in Poly(butyl cyanoacrylate)-Based Polymeric Microbubbles
Journal Article (2020)
Liu, Mengjiao
Dasgupta, Anshuman
Koczera, Patrick
Schipper, Sandra
Rommel, Dirk
Shi, Yang
Kiessling, Fabian
Lammers, Twan (Corresponding author)
Cancer nanomedicine meets immunotherapy: opportunities and challenges
Journal Article (2020)
Sun, Qingxue
Bai, Xiangyang
Sofias, Alexandros Marios
van der Meel, Roy
Ruiz-Hernandez, Eduardo
Storm, Gert
Hennink, Wim E.
De Geest, Bruno G.
Kiessling, Fabian
Yu, Hai-Jun
Lammers, Twan (Corresponding author)
Shi, Yang (Corresponding author)
Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles
Journal Article (2020)
Wang, Bi
Van Herck, Simon
Chen, Yong
Bai, Xiangyang
Zhong, Zifu
Deswarte, Kim
Lambrecht, Bart N.
Sanders, Niek N.
Lienenklaus, Stefan
Scheeren, Hans W.
David, Sunil A.
Kiessling, Fabian
Lammers, Twan (Corresponding author)
De Geest, Bruno G.
Shi, Yang (Corresponding author)
Clinical Translation of Nanomedicine and Biomaterials for Cancer Immunotherapy: Progress and Perspectives
Journal Article (2020)
Shi, Yang (Corresponding author)
Biotin-decorated all-HPMA polymeric micelles for paclitaxel delivery
Contribution to a book, Journal Article (2020)
Wang, Yan
van Steenbergen, Mies J.
Beztsinna, Nataliia
Shi, Yang
Lammers, Twan
van Nostrum, Cornelus F.
Hennink, Wim E. (Corresponding author)
Combining Nanomedicine and Immunotherapy
Journal Article (2019)
Shi, Yang (Corresponding author)
Lammers, Twan (Corresponding author)
Smart cancer nanomedicine
Journal Article (2019)
van der Meel, Roy
Sulheim, Einar
Shi, Yang
Kießling, Fabian
Mulder, Willem J. M.
Lammers, Twan (Corresponding author)
Engineering Nanoparticles to Reprogram the Tumor Immune Microenvironment for Improved Cancer Immunotherapy
Journal Article (2019)
Saeed, Madiha
Gao, Jing
Shi, Yang
Lammers, Twan
Yu, Haijun
Nanomedicine and macroscale materials in immuno-oncology
Journal Article (2019)
Sun, Qingxue
Barz, Matthias
De Geest, Bruno G.
Diken, Mustafa
Hennink, Wim E.
Kießling, Fabian
Lammers, Twan (Corresponding author)
Shi, Yang (Corresponding author)
PLGA-Based Nanoparticles in Cancer Treatment
Journal Article (2018)
Rezvantalab, Sima
Drude, Natascha
Moraveji, Mostafa Keshavarz (Corresponding author)
Güvener, Nihan
Koons, Emily Kate
Shi, Yang
Lammers, Twan
Kießling, Fabian (Corresponding author)
PBCA-based polymeric microbubbles for molecular imaging and drug delivery
Contribution to a conference proceedings, Journal Article (2017)
Koczera, Patrick
Appold, Lia
Shi, Yang
Liu, Mengjiao
Dasgupta, Anshuman
Pathak, Vertika
Ojha, Tarun
Fokong, Stanley
Wu, Zhuojun
van Zandvoort, Marc
Iranzo, Olga
Kuehne, Alexander J. C.
Pich, Andrij
Kießling, Fabian
Lammers, Twan (Corresponding author)
Pharmacological and physical vessel modulation strategies to improve EPR-mediated drug targeting to tumors☆
Contribution to a book, Journal Article (2017)
Ojha, Tarun
Pathak, Vertika
Shi, Yang
Hennink, Wim E.
Moonen, Chrit T. W.
Storm, Gert
Kiessling, Fabian (Corresponding author)
Lammers, Twan (Corresponding author)
Enhancing Tumor Penetration of Nanomedicines
Journal Article (2017)
Sun, Qingxue
Ojha, Tarun
Kiessling, Fabian
Lammers, Twan
Shi, Yang (Corresponding author)
Singlet oxygen-responsive micelles for enhanced photodynamic therapy
Journal Article (2017)
Li, Xiaodan
Gao, Min
Xin, Keting
Zhang, Ling
Ding, Dan
Kong, Deling
Wang, Zheng
Shi, Yang
Kiessling, Fabian
Lammers, Twan
Cheng, Jianjun
Zhao, Yanjun (Corresponding author)
Tumor-targeted nanomedicines for cancer theranostics
Journal Article (2017)
Arranja, Alexandra G.
Pathak, Vertika
Lammers, Twan (Corresponding author)
Shi, Yang (Corresponding author)
Physicochemical Characterization of the Shell Composition of PBCA-Based Polymeric Microbubbles
Contribution to a book, Journal Article (2017)
Appold, Lia
Shi, Yang
Rütten, Stephan
Kühne, Alexander J. C.
Pich, Andrij
Kießling, Fabian
Lammers, Twan (Corresponding author)
Physico-Chemical Strategies to Enhance Stability and Drug Retention of Polymeric Micelles for Tumor-Targeted Drug Delivery
Contribution to a book, Journal Article (2016)
Shi, Yang
Lammers, Twan
Storm, Gert
Hennink, Wim E. (Corresponding author)
Fluorinated polyurethane scaffolds for 19F magnetic resonance imaging
Journal Article (2017)
Lammers, Twan (Corresponding author)
Mertens, Marianne Elisabeth
Schuster, Philipp
Rahimi, Khosrow
Shi, Yang
Schulz, Volkmar
Kühne, Alexander J. C.
Jockenhövel, Stefan
Kießling, Fabian (Corresponding author)
Refinement of adsorptive coatings for fluorescent riboflavin-receptor-targeted iron oxide nanoparticles
Journal Article (2016)
Tsvetkova, Yoanna
Beztsinna, Nataliia
Jayapaul, Jabadurai
Weiler, Marek
Arns, Susanne
Shi, Yang
Lammers, Twan
Kießling, Fabian (Corresponding author)
Complete Regression of Xenograft Tumors upon Targeted Delivery of Paclitaxel via Π-Π Stacking Stabilized Polymeric Micelles
Journal Article (2015)
Shi, Yang
van der Meel, Roy
Theek, Benjamin
Oude Blenke, Erik
Pieters, Ebel H. E.
Fens, Marcel H. A. M.
Ehling, Josef
Schiffelers, Raymond M.
Storm, Gert
van Nostrum, Cornelus F.
Lammers, Twan
Hennink, Wim E. (Corresponding author)
Long circulating and stable polymeric micelles for targeted delivery of paclitaxel
Journal Article (2015)
Shi, Yang (Corresponding author)
Lammers, Twan
van Nostrum, Cornelus
Hennink, Wim E.
PEG-pHPMAm-based polymeric micelles loaded with doxorubicin-prodrugs in combination antitumor therapy with oncolytic vaccinia viruses
Journal Article (2014)
Ruiz-Hernandez, Eduardo
Hess, Michael
Melen, Gustavo J.
Theek, Benjamin
Talelli, Marina
Shi, Yang
Ozbakir, Burcin
Teunissen, Erik A.
Ramirez, Manuel
Möckel, Diana
Kießling, Fabian
Storm, Gert
Scheeren, Hans W.
Hennink, Wim E.
Szalay, Aladar A.
Strizker, Jochen (Corresponding author)
Lammers, Twan (Corresponding author)