Person

Dr.

Alexandros Marios Sofias

Alexandros Marios Sofias Urheberrecht: © Privat
Lehrstuhl für Experimentelle Molekulare Bildgebung

Adresse

Gebäude: CBMS

Raum: 109

Forckenbeckstraße 55

52074 Aachen

Kontakt

WorkPhone
Telefon: +49 241 80 85622
 

Dr. Alexandros Marios Sofias ist Leiter der Forschungsgruppe "Immune Cell Targeting and Imaging" am Institut für Experimentelle Molekulare Bildgebung (ExMI, RWTH). Er hat einen PhD in Nanomedizin (2019), einen MSc in Pharmazeutischen Wissenschaften (2016) und ein Diplom in Pharmazie (2014). Seine Forschung konzentriert sich auf die Entschlüsselung des komplizierten In-vivo-Verhaltens von Krebs-Nanomedizin durch multimodale und multiskalige Bildgebung und die Entwicklung von Nanoimmuntherapeutika zur gezielten Beeinflussung des krebsassoziierten Immunsystems. Er ist Ko-Vorsitzender der Studiengruppe Image-Guided Drug Delivery (IGDD) der Europäischen Gesellschaft für Molekulare Bildgebung (ESMI).

Ausgewählte Publikationen:

  1. Sofias AM*, Toner YC, Meerwaldt AE, […], Pérez-Medina C, Mulder WJM, Hak S*, “Tumor targeting by αvβ3-integrin-specific lipid nanoparticles occurs via phagocyte hitchhiking”, ACS Nano (2020).
  2. Sofias AM*, Bjørkøy G, Ochando J, […], Lammers T, Mulder WJM, Hak S*, “Cyclid Arginine–Glycine–Aspartate-decorated lipid nanoparticle targeting towards inflammatory lesions involves hitchhiking with phagocytes”, Advanced Science (2021).
  3. Sofias AM*, Combes F, Koschmieder S, Storm G, Lammers T*, “A Paradigm Shift in Cancer nanomedicine: From traditional tumor targeting to leveraging the immune system”, Drug Discovery Today (2021).
 

Publikationen

Titel Autor(en)
Profiling target engagement and cellular uptake of cRGD-decorated clinical-stage core-crosslinked polymeric micelles
Fachzeitschriftenartikel (2022)
De Lorenzi, Federica
Rizzo, Larissa Yokota
Daware, Rasika
Motta, Alessandro
Baues, Maike
Bartneck, Matthias
Vogt, Michael
van Zandvoort, Marc
Kaps, Leonard
Hu, Qizhi
Thewissen, Marielle
Casettari, Luca
Rijcken, Cristianne J. F.
Kiessling, Fabian
Sofias, Alexandros Marios
Lammers, Twan (Corresponding author)
Cyclic Arginine-Glycine-Aspartate‐Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes
Fachzeitschriftenartikel (2021)
Sofias, Alexandros Marios (Corresponding author)
Bjørkøy, Geir
Ochando, Jordi
Sønstevold, Linda
Hegvik, Maria
Davies, Catharina de Lange
Haraldseth, Olav
Lammers, Twan
Mulder, Willem J. M.
Hak, Sjoerd (Corresponding author)
Progression of Myeloproliferative Neoplasms (MPN): Diagnostic and Therapeutic Perspectives
Buchbeitrag, Fachzeitschriftenartikel (2021)
Baumeister, Julian
Chatain, Nicolas
Sofias, Alexandros Marios
Lammers, Twan
Koschmieder, Steffen (Corresponding author)
A paradigm shift in cancer nanomedicine: from traditional tumor targeting to leveraging the immune system
Fachzeitschriftenartikel (2021)
Sofias, Alexandros Marios (Corresponding author)
Combes, Francis
Koschmieder, Steffen
Storm, Gert
Lammers, Twan (Corresponding author)
Therapeutic and diagnostic targeting of fibrosis in metabolic, proliferative and viral disorders
Fachzeitschriftenartikel (2021)
Sofias, Alexandros Marios (Corresponding author)
De Lorenzi, Federica
Peña, Quim
Azadkhah Shalmani, Armin
Vucur, Mihael
Wang, Jiong-Wei
Kiessling, Fabian
Shi, Yang
Consolino, Lorena (Corresponding author)
Storm, Gert (Corresponding author)
Lammers, Twan (Corresponding author)
Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies
Fachzeitschriftenartikel (2021)
Escudé Martinez de Castilla, Pol
Tong, Lingjun
Huang, Chenyuan
Sofias, Alexandros Marios
Pastorin, Giorgia
Chen, Xiaoyuan
Storm, Gert
Schiffelers, Raymond M. (Corresponding author)
Wang, Jiong-Wei (Corresponding author)
Optical imaging of the whole-body to cellular biodistribution of clinical-stage PEG-b-pHPMA-based core-crosslinked polymeric micelles
Buchbeitrag, Fachzeitschriftenartikel (2020)
Biancacci, Ilaria
Sun, Qingxue
Möckel, Diana
Gremse, Felix
Rosenhain, Stefanie
Kiessling, Fabian
Bartneck, Matthias
Hu, Qizhi
Thewissen, Marielle
Storm, Gert
Hennink, Wim E.
Shi, Yang
Rijcken, Cristianne J. F. (Corresponding author)
Lammers, Twan (Corresponding author)
Sofias, Alexandros Marios (Corresponding author)
Dexamethasone nanomedicines for COVID-19
Fachzeitschriftenartikel (2020)
Lammers, Twan (Corresponding author)
Sofias, Alexandros Marios
van der Meel, Roy
Schiffelers, Raymond
Storm, Gert
Tacke, Frank
Koschmieder, Steffen
Brümmendorf, Tim H.
Kiessling, Fabian
Metselaar, Josbert M. (Corresponding author)
Cancer nanomedicine meets immunotherapy: opportunities and challenges
Fachzeitschriftenartikel (2020)
Sun, Qingxue
Bai, Xiangyang
Sofias, Alexandros Marios
van der Meel, Roy
Ruiz-Hernandez, Eduardo
Storm, Gert
Hennink, Wim E.
De Geest, Bruno G.
Kiessling, Fabian
Yu, Hai-Jun
Lammers, Twan (Corresponding author)
Shi, Yang (Corresponding author)