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Dr. Alexandros Marios Sofias is the head of the “Immune Cell Targeting and Imaging” Research Group, at the Institute for Experimental Molecular Imaging (ExMI, RWTH). He holds a PhD in Nanomedicine (2019), a MSc in Pharmaceutical Sciences (2016), and a Diploma in Pharmacy (2014). His research focuses on unraveling the intricate in vivo fate of cancer nanomedicine via multimodal and multiscale imaging, and developing nanoimmunotherapeutics for targeting and manipulating the cancer-associated immune system. He serves as Co-Chair of the Image-Guided Drug Delivery (IGDD) Study Group of the European Society for Molecular Imaging (ESMI).

Selected publications:

1. Sofias AM*, Toner YC, Meerwaldt AE, […], Pérez-Medina C, Mulder WJM, Hak S*, “Tumor targeting by α_vβ₃-integrin-specific lipid nanoparticles occurs via phagocyte hitchhiking”, ACS Nano (2020).
   
2. Sofias AM*, Bjørkøy G, Ochando J, […], Lammers T, Mulder WJM, Hak S*, “Cyclid Arginine–Glycine–Aspartate-decorated lipid nanoparticle targeting towards inflammatory lesions involves hitchhiking with phagocytes”, Advanced Science (2021).
   
3. Sofias AM*, Combes F, Koschmieder S, Storm G, Lammers T*, “A Paradigm Shift in Cancer nanomedicine: From traditional tumor targeting to leveraging the immune system”, Drug Discovery Today (2021).

 

Publications

Title	Author(s)
Profiling target engagement and cellular uptake of cRGD-decorated clinical-stage core-crosslinked polymeric micelles Journal Article (2022)	De Lorenzi, Federica Rizzo, Larissa Yokota Daware, Rasika Motta, Alessandro Baues, Maike Bartneck, Matthias Vogt, Michael van Zandvoort, Marc Kaps, Leonard Hu, Qizhi Thewissen, Marielle Casettari, Luca Rijcken, Cristianne J. F. Kiessling, Fabian Sofias, Alexandros Marios Lammers, Twan (Corresponding author)
Cyclic Arginine-Glycine-Aspartate‐Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes Journal Article (2021)	Sofias, Alexandros Marios (Corresponding author) Bjørkøy, Geir Ochando, Jordi Sønstevold, Linda Hegvik, Maria Davies, Catharina de Lange Haraldseth, Olav Lammers, Twan Mulder, Willem J. M. Hak, Sjoerd (Corresponding author)
Progression of Myeloproliferative Neoplasms (MPN): Diagnostic and Therapeutic Perspectives Contribution to a book, Journal Article (2021)	Baumeister, Julian Chatain, Nicolas Sofias, Alexandros Marios Lammers, Twan Koschmieder, Steffen (Corresponding author)
A paradigm shift in cancer nanomedicine: from traditional tumor targeting to leveraging the immune system Journal Article (2021)	Sofias, Alexandros Marios (Corresponding author) Combes, Francis Koschmieder, Steffen Storm, Gert Lammers, Twan (Corresponding author)
Therapeutic and diagnostic targeting of fibrosis in metabolic, proliferative and viral disorders Journal Article (2021)	Sofias, Alexandros Marios (Corresponding author) De Lorenzi, Federica Peña, Quim Azadkhah Shalmani, Armin Vucur, Mihael Wang, Jiong-Wei Kiessling, Fabian Shi, Yang Consolino, Lorena (Corresponding author) Storm, Gert (Corresponding author) Lammers, Twan (Corresponding author)
Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies Journal Article (2021)	Escudé Martinez de Castilla, Pol Tong, Lingjun Huang, Chenyuan Sofias, Alexandros Marios Pastorin, Giorgia Chen, Xiaoyuan Storm, Gert Schiffelers, Raymond M. (Corresponding author) Wang, Jiong-Wei (Corresponding author)
Optical imaging of the whole-body to cellular biodistribution of clinical-stage PEG-b-pHPMA-based core-crosslinked polymeric micelles Contribution to a book, Journal Article (2020)	Biancacci, Ilaria Sun, Qingxue Möckel, Diana Gremse, Felix Rosenhain, Stefanie Kiessling, Fabian Bartneck, Matthias Hu, Qizhi Thewissen, Marielle Storm, Gert Hennink, Wim E. Shi, Yang Rijcken, Cristianne J. F. (Corresponding author) Lammers, Twan (Corresponding author) Sofias, Alexandros Marios (Corresponding author)
Dexamethasone nanomedicines for COVID-19 Journal Article (2020)	Lammers, Twan (Corresponding author) Sofias, Alexandros Marios van der Meel, Roy Schiffelers, Raymond Storm, Gert Tacke, Frank Koschmieder, Steffen Brümmendorf, Tim H. Kiessling, Fabian Metselaar, Josbert M. (Corresponding author)
Cancer nanomedicine meets immunotherapy: opportunities and challenges Journal Article (2020)	Sun, Qingxue Bai, Xiangyang Sofias, Alexandros Marios van der Meel, Roy Ruiz-Hernandez, Eduardo Storm, Gert Hennink, Wim E. De Geest, Bruno G. Kiessling, Fabian Yu, Hai-Jun Lammers, Twan (Corresponding author) Shi, Yang (Corresponding author)