Alexandros Marios Sofias

Alexandros Marios Sofias Copyright: © Private
Lehrstuhl für Experimentelle Molekulare Bildgebung


Building: CBMS

Room: 109

Forckenbeckstraße 55

52074 Aachen


Phone: +49 241 80 85622

Dr. Alexandros Marios Sofias is the head of the “Immune Cell Targeting and Imaging” Research Group, at the Institute for Experimental Molecular Imaging (ExMI, RWTH). He holds a PhD in Nanomedicine (2019), a MSc in Pharmaceutical Sciences (2016), and a Diploma in Pharmacy (2014). His research focuses on unraveling the intricate in vivo fate of cancer nanomedicine via multimodal and multiscale imaging, and developing nanoimmunotherapeutics for targeting and manipulating the cancer-associated immune system. He serves as Co-Chair of the Image-Guided Drug Delivery (IGDD) Study Group of the European Society for Molecular Imaging (ESMI).

Selected publications:

  1. Sofias AM*, Toner YC, Meerwaldt AE, […], Pérez-Medina C, Mulder WJM, Hak S*, “Tumor targeting by αvβ3-integrin-specific lipid nanoparticles occurs via phagocyte hitchhiking”, ACS Nano (2020).
  2. Sofias AM*, Bjørkøy G, Ochando J, […], Lammers T, Mulder WJM, Hak S*, “Cyclid Arginine–Glycine–Aspartate-decorated lipid nanoparticle targeting towards inflammatory lesions involves hitchhiking with phagocytes”, Advanced Science (2021).
  3. Sofias AM*, Combes F, Koschmieder S, Storm G, Lammers T*, “A Paradigm Shift in Cancer nanomedicine: From traditional tumor targeting to leveraging the immune system”, Drug Discovery Today (2021).


Title Author(s)
Cyclic Arginine-Glycine-Aspartate‐Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes
Journal Article (2021)
Sofias, Alexandros Marios (Corresponding author)
Bjørkøy, Geir
Ochando, Jordi
Sønstevold, Linda
Hegvik, Maria
Davies, Catharina de Lange
Haraldseth, Olav
Lammers, Twan
Mulder, Willem J. M.
Hak, Sjoerd (Corresponding author)
Optical imaging of the whole-body to cellular biodistribution of clinical-stage PEG-b-pHPMA-based core-crosslinked polymeric micelles
Contribution to a book, Journal Article (2020)
Biancacci, Ilaria
Sun, Qingxue
Möckel, Diana
Gremse, Felix
Rosenhain, Stefanie
Kiessling, Fabian
Bartneck, Matthias
Hu, Qizhi
Thewissen, Marielle
Storm, Gert
Hennink, Wim E.
Shi, Yang
Rijcken, Cristianne J. F. (Corresponding author)
Lammers, Twan (Corresponding author)
Sofias, Alexandros Marios (Corresponding author)
Dexamethasone nanomedicines for COVID-19
Journal Article (2020)
Lammers, Twan (Corresponding author)
Sofias, Alexandros Marios
van der Meel, Roy
Schiffelers, Raymond
Storm, Gert
Tacke, Frank
Koschmieder, Steffen
Brümmendorf, Tim H.
Kiessling, Fabian
Metselaar, Josbert M. (Corresponding author)
Cancer nanomedicine meets immunotherapy: opportunities and challenges
Journal Article (2020)
Sun, Qingxue
Bai, Xiangyang
Sofias, Alexandros Marios
van der Meel, Roy
Ruiz-Hernandez, Eduardo
Storm, Gert
Hennink, Wim E.
De Geest, Bruno G.
Kiessling, Fabian
Yu, Hai-Jun
Lammers, Twan (Corresponding author)
Shi, Yang (Corresponding author)