Person
Dr.Josbert Maarten Metselaar
Lehrstuhl für Experimentelle Molekulare Bildgebung
Address
Building: CBMS
Room: 109
Forckenbeckstraße 55
52074 Aachen
Josbert (Bart) (PharmD Utrecht University) obtained his PhD at in Pharmaceutics and Immunology in 2003 with a thesis novel targeted drug formulations for inflammation. After a postdoctorate in 2005 he founded the company Enceladus Pharmaceuticals BV. With this company he succeeded in conducting a series of preclinical and clinical studies on two different liposomal nanomedicine products. He could finance these studies by securing a series of research grants, two major company awards, various investments and pharmaceutical partnerships.
Since 2012 Bart has been working as a part-time associate professor of advanced drug delivery at the University of Twente. In 2015 he took a part-time group leader position at the RWTH Aachen. There he expanded his research into the development of liposomal and polymeric nanomedicines for the treatment of hematological cancers and solid tumors. He helped realize new funding for tumor-targeted drug delivery through research grants from DRG and BMBF.
Publications
| Title | Author(s) |
|---|---|
| A phase I first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone in patients with progressive multiple myeloma Journal Article (2023) | Metselaar, Josbert M. (Corresponding author) Lammers, Twan Boquoi, Amelie Fenk, Roland Testaquadra, Fabio Schemionek-Reinders, Mirle Kiessling, Fabian Isfort, Susanne Wilop, Stefan Crysandt, Martina |
| Effect of Radical Polymerization Method on Pharmaceutical Properties of Π Electron-Stabilized HPMA-Based Polymeric Micelles Journal Article (2023) | Shalmani, Armin Azadkhah Ahmed, Zaheer Sheybanifard, Maryam Wang, Alec Weiler, Marek Buhl, Eva Miriam Klinkenberg, Geir Schmid, Ruth Hennink, Wim Kiessling, Fabian Metselaar, Josbert M. Lammers, Twan (Corresponding author) Peña, Quim (Corresponding author) Shi, Yang (Corresponding author) |
| Metallodrugs in cancer nanomedicine Journal Article (2022) | Peña, Quim Wang, Alec Zaremba, Orysia Shi, Yang Scheeren, Hans W. Metselaar, Josbert Maarten Kiessling, Fabian Pallares, Roger M. Wuttke, Stefan (Corresponding author) Lammers, Twan (Corresponding author) |
| Ultrasound-directed enzyme-prodrug therapy (UDEPT) using self-immolative doxorubicin derivatives Journal Article (2022) | Roemhild, Karolin Besse, Helena C. Wang, Bi Peña, Quim Sun, Qingxue Omata, Daiki Ozbakir, Burcin Bos, Clemens Scheeren, Hans W. Storm, Gert Metselaar, Josbert M. Yu, Haijun Knüchel-Clarke, Ruth Kiessling, Fabian Moonen, Chrit T. W. Deckers, Roel (Corresponding author) Shi, Yang (Corresponding author) Lammers, Twan (Corresponding author) |
| Monitoring EPR Effect Dynamics during Nanotaxane Treatment with Theranostic Polymeric Micelles Contribution to a book, Journal Article (2022) | Biancacci, Ilaria De Lorenzi, Federica Theek, Benjamin Bai, Xiangyang May, Jan-Niklas Consolino, Lorena Baues, Maike Moeckel, Diana Gremse, Felix Stillfried, Saskia El Shafei, Asmaa Benderski, Karina Azadkhah Shalmani, Armin Wang, Alec Momoh, Jeffrey Peña, Quim Buhl, Eva Miriam Buyel, Johannes Felix Hennink, Wim Kießling, Fabian Metselaar, Josbert Shi, Yang (Corresponding author) Lammers, Twan (Corresponding author) |
| Intravenous pegylated liposomal prednisolone outperforms intramuscular methylprednisolone in treating rheumatoid arthritis flares: A randomized controlled clinical trial Contribution to a book, Journal Article (2021) | Metselaar, Josbert M. Middelink, Leonie M. Wortel, Cornelis H. Bos, Reinhard van Laar, Jacob M. Vonkeman, Harald E. Westhovens, Rene Lammers, Twan Yao, Siu-Long Kothekar, Mudgal Raut, Atul Bijlsma, Johannes W. J. |
| Development of 89Zr-radiolabeled paclitaxel-loaded polymeric micelles for potential applications in personalized treatment of triple-negative breast cancer Abstract, Contribution to a conference proceedings, Journal Article (2022) | Sadeghzadeh, Masoud Berlanga, Sara Sanchez Hertel, Fabian Florea, Alexandru Sahnoun, Sabri E. M. Wang, Alec Römhild, Karolin May, Jan-Niklas Peña, Quim Shi, Yang Metselaar, Josbert M. Lammers, Twan Mottaghy, Felix Manuel |
| A review of the clinical applications of drug delivery systems for the treatment of ocular anterior segment inflammation Journal Article (2020) | Wong, Chee Wai Metselaar, Josbert M. Storm, Gert (Corresponding author) Wong, Tina T. (Corresponding author) |
| Π electron-stabilized polymeric micelles potentiate docetaxel therapy in advanced-stage gastrointestinal cancer Journal Article (2021) | Liang, Chenghua Bai, Xiangyang Qi, Cuiling Sun, Qingxue Han, Xiaoyan Lan, Tianyun Zhang, Haibo Zheng, Xiaoming Liang, Rongpu Jiao, Ju Zheng, Zongheng Fang, Jiafeng Lei, Purun Wang, Yan Möckel, Diana Metselaar, Josbert M. Storm, Gert Hennink, Wim E. Kiessling, Fabian Wei, Hongbo (Corresponding author) Lammers, Twan Shi, Yang (Corresponding author) Wei, Bo (Corresponding author) |
| Systematic evaluation of design features enables efficient selection of ? electron-stabilized polymeric micelles Journal Article (2020) | Sheybanifard, Maryam Beztsinna, Nataliia Bagheri, Mahsa Buhl, Eva Miriam Bresseleers, Jaleesa Varela-Moreira, Aida Shi, Yang van Nostrum, Cornelus F. van der Pluijm, Gabri Storm, Gert Hennink, Wim E. Lammers, Twan Metselaar, Josbert M. (Corresponding author) |
| Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance Journal Article (2020) | Dadfar, Seyed Mohammadali Camozzi, Denise Darguzyte, Milita Roemhild, Karolin Varvarà, Paola Metselaar, Josbert M. Banala, Srinivas Straub, Marcel Güvener, Nihan Engelmann, Ulrich Slabu, Ioana Buhl, Miriam van Leusen, Jan Kögerler, Paul Hermanns-Sachweh, Benita Schulz, Volkmar Kiessling, Fabian Lammers, Twan (Corresponding author) |
| Dexamethasone nanomedicines for COVID-19 Journal Article (2020) | Lammers, Twan (Corresponding author) Sofias, Alexandros Marios van der Meel, Roy Schiffelers, Raymond Storm, Gert Tacke, Frank Koschmieder, Steffen Brümmendorf, Tim H. Kiessling, Fabian Metselaar, Josbert M. (Corresponding author) |
| Complete Tumor Regression by Liposomal Bortezomib in a Humanized Mouse Model of Multiple Myeloma Journal Article (2020) | Deshantri, Anil K. Fens, Marcel H. A. M. Ruiter, Ruud W. J. Metselaar, Josbert M. Storm, Gert Mandhane, Sanjay N. Graat, Gerard H. M. Lentjes, Eef G. W. Yuan, Huipin de Bruijn, Joost D. Mutis, Tuna Martens, Anton C. M. Groen, Richard W. J. (Corresponding author) Schiffelers, Raymond M. (Corresponding author) |
| A randomized trial of liposomal prednisolone (LIPMAT) to enhance radiocephalic fistula maturation: a pilot study Journal Article (2020) | Voorzaat, Bram M. van der Bogt, K. E. A. Bezhaeva, Taisiya van Schaik, Jan Eefting, Daniel van der Putten, Karien van Nieuwenhuizen, Roos C. Groeneveld, Johannes O. Hoogeveen, Ellen K. van der Meer, Irene M. Statius van Eps, Randolph G. Vogt, Liffert Huisman, Laurens Gabreëls, Bas A. Th F. Boom, Henk Verburgh, Cornelis A. Boon, Diederik Metselaar, Josbert M. Weijmer, Marcel C. Rotmans, Joris I. (Corresponding author) |
| A Doxorubicin-Glucuronide Prodrug Released from Nanogels Activated by High-Intensity Focused Ultrasound Liberated β-Glucuronidase Contribution to a book, Journal Article (2020) | Besse, Helena C. Chen, Yinan Scheeren, Hans W. Metselaar, Josbert M. Lammers, Twan Moonen, Chrit T. W. Hennink, Wim E. Deckers, Roel (Corresponding author) |
| Liposomal Delivery Improves the Efficacy of Prednisolone to Attenuate Renal Inflammation in a Mouse Model of Acute Renal Allograft Rejection Journal Article (2020) | van Alem, Carla M. A. Schmidbauer, Martina Rong, Song Derlin, Katja Schmitz, Jessica Bräsen, Jan H. Thorenz, Anja Chen, Rongjun Ruben, Jurjen M. Winter, Elizabeth M. Schilperoort, Maaike Kooijman, Sander Lalai, Reshma A. Metselaar, Josbert Maarten Klemann, Christian Meier, Martin van Kooten, Cees Gueler, Faikah Rotmans, Joris I. (Corresponding author) |
| Challenges in nanomedicine clinical translation Journal Article (2020) | Metselaar, Josbert M. (Corresponding author) Lammers, Twan (Corresponding author) |
| Liposomal dexamethasone inhibits tumor growth in an advanced human-mouse hybrid model of multiple myeloma Journal Article (2019) | Deshantri, Anil K. Fens, Marcel H. Ruiter, Ruud W. J. Metselaar, Josbert M. Storm, Gert van Bloois, Louis Varela-Moreira, Aida Mandhane, Sanjay N. Mutis, Tuna Martens, Anton C. M. Groen, Richard W. J. Schiffelers, Raymond M. (Corresponding author) |
| Development and characterization of liposomal formulation of bortezomib Journal Article (2019) | Deshantri, Anil K. Metselaar, Josbert M. Zagkou, Stavroula Storm, Gert Mandhane, Sanjay N. Fens, Marcel H. A. M. Schiffelers, Raymond M. (Corresponding author) |
| ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer Journal Article (2019) | Kuninty, Praneeth R. Bansal, Ruchi De Geus, Susanna W. L. Mardhian, Deby F. Schnittert, Jonas van Baarlen, Joop Storm, Gert Bijlsma, Maarten F. van Laarhoven, Hanneke W. Metselaar, Josbert M. Kuppen, Peter J. K. Vahrmeijer, Alexander L. Östman, Arne Sier, Cornelis F. M. Prakash, Jai (Corresponding author) |
| Liposome-induced hypersensitivity reactions: Risk reduction by design of safe infusion protocols in pigs Contribution to a conference proceedings, Journal Article (2019) | Fülöp, Tamás Kozma, Gergely T. Vashegyi, Ildikó Mészáros, Tamás Rosivall, László Urbanics, Rudolf Storm, Gert Metselaar, Josbert M. (Corresponding author) Szebeni, János (Corresponding author) |
| From design to the clinic: practical guidelines for translating cardiovascular nanomedicine Journal Article (2018) | Cicha, Iwona (Corresponding author) Chauvierre, Cédric Texier, Isabelle Cabella, Claudia Metselaar, Josbert M. Szebeni, János Dézsi, László Alexiou, Christoph Rouzet, François Storm, Gert Stroes, Erik Bruce, Donald MacRitchie, Neil Maffia, Pasquale Letourneur, Didier |
| Imaging fibroblast activation protein to monitor therapeutic effects of neutralizing interleukin-22 in collagen-induced arthritis Journal Article (2018) | van der Geest, Tessa Roeleveld, Debbie M. Walgreen, Birgitte Helsen, Monique M. Nayak, Tapan K. Klein, Christian Hegen, Martin Storm, Gert Metselaar, Josbert M. van den Berg, Wim B. van der Kraan, Peter M. Laverman, Peter Boerman, Otto C. Koenders, Marije I. (Corresponding author) |
| Effect of Formulation and Processing Parameters on the Size of mPEG-b-p(HPMA-Bz) Polymeric Micelles Journal Article (2018) | Bagheri, Mahsa Bresseleers, Jaleesa Varela-Moreira, Aida Sandre, Olivier Meeuwissen, Silvie A. Schiffelers, Raymond M. Metselaar, Josbert M. van Nostrum, Cornelus F. van Hest, Jan C. M. Hennink, Wim E. (Corresponding author) |
| Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis Journal Article (2018) | Wong, Chee Wai Czarny, Bertrand Metselaar, Josbert M. Ho, Candice Ng, Si Rui Barathi, Amutha Veluchamy Storm, Gert (Corresponding author) Wong, Tina T. (Corresponding author) |
| Local delivery of liposomal prednisolone leads to an anti-inflammatory profile in renal ischaemia-reperfusion injury in the rat Journal Article (2018) | van Alem, Carla M. A. Boonstra, Mark Prins, Jurriën Bezhaeva, Taisiya van Essen, Mieke F. Ruben, Jurjen M. Vahrmeijer, Alexander L. van der Veer, Eric P. De Fijter, Johan W. Reinders, Marlies E. Meijer, Onno Metselaar, Josbert M. van Kooten, Cees Rotmans, Joris I. (Corresponding author) |
| Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization Journal Article (2018) | Hua, Susan (Corresponding author) de Matos, Maria B. C. Metselaar, Josbert M. Storm, Gert |
| Comparative analysis of nanosystems’ effects on human endothelial and monocytic cell functions Journal Article (2018) | Matuszak, Jasmin Dörfler, Philipp Lyer, Stefan Unterweger, Harald Juenet, Maya Chauvierre, Cédric Alaarg, Amr Franke, Danielle Almer, Gunter Texier, Isabelle Metselaar, Josbert M. Prassl, Ruth Alexiou, Christoph Mangge, Harald Letourneur, Didier Cicha, Iwona (Corresponding author) |
| In Vitro Evaluation of Anti-Aggregation and Degradation Behavior of PEGylated Polymeric Nanogels under In Vivo Like Conditions Contribution to a book, Journal Article (2017) | Chen, Yinan Dakwar, George R. Braeckmans, Kevin Lammers, Twan Hennink, Wim E. (Corresponding author) Metselaar, Josbert M. (Corresponding author) |
| Applying nanomedicine in maladaptive inflammation and angiogenesis☆ Contribution to a book, Journal Article (2017) | Alaarg, Amr Pérez-Medina, Carlos Metselaar, Josbert M. Nahrendorf, Matthias Fayad, Zahi A. Storm, Gert Mulder, Willem J. M. (Corresponding author) |
| Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction Journal Article (2017) | Allijn, Iris E. Czarny, Bertrand M. S. Wang, Xiaoyuan Chong, Suet Yen Weiler, Marek da Silva, Acarilia Eduardo Metselaar, Josbert M. Lam, Carolyn Su Ping Pastorin, Giorgia de Kleijn, Dominique P. V. Storm, Gert Wang, Jiong-Wei Schiffelers, Raymond M. (Corresponding author) |
| In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow Journal Article (2017) | van der Meer, Laurens T. Terry, Samantha Y. A. van Ingen Schenau, Dorette S. Andree, Kiki C. Franssen, Gerben M. Roeleveld, Debbie M. Metselaar, Josbert M. Reinheckel, Thomas Hoogerbrugge, Peter M. Boerman, Otto C. van Leeuwen, Frank N. (Corresponding author) |
| A systematic comparison of clinically viable nanomedicines targeting HMG-CoA reductase in inflammatory atherosclerosis Journal Article (2017) | Alaarg, Amr Senders, Max L. Varela-Moreira, Aida Pérez-Medina, Carlos Zhao, Yiming Tang, Jun Fay, Francois Reiner, Thomas Fayad, Zahi A. Hennink, Wim E. Metselaar, Josbert M. Mulder, Willem J. M. (Corresponding author) Storm, Gert (Corresponding author) |
| Overcoming multidrug resistance using folate receptor-targeted and pH-responsive polymeric nanogels containing covalently entrapped doxorubicin Journal Article (2017) | Chen, Y. (Corresponding author) Tezcan, O. Li, D. Beztsinna, N. Lou, B. Etrych, T. Ulbrich, K. Metselaar, J. M. Lammers, T. Hennink, W. E. (Corresponding author) |
| Liposomal Treatment of Experimental Arthritis Can Be Monitored Noninvasively with a Radiolabeled Anti-Fibroblast Activation Protein Antibody Journal Article (2017) | van der Geest, Tessa (Corresponding author) Laverman, Peter Gerrits, Danny Walgreen, Birgitte Helsen, Monique M. Klein, Christian Nayak, Tapan K. Storm, Gert Metselaar, Josbert M. Koenders, Marije I. Boerman, Otto C. |
| Glucocorticoid receptor antagonism reverts docetaxel resistance in human prostate cancer Journal Article (2015) | Kroon, Jan Puhr, Martin Buijs, Jeroen T. van der Horst, Geertje Hemmer, Daniëlle M. Marijt, Koen A. Hwang, Ming S. Masood, Motasim Grimm, Stefan Storm, Gert Metselaar, Josbert M. Meijer, Onno C. Culig, Zoran van der Pluijm, Gabri (Corresponding author) |
| Radionuclide imaging of liposomal drug delivery Journal Article (2016) | van der Geest, Tessa (Corresponding author) Laverman, Peter Metselaar, Josbert M. Storm, Gert Boerman, Otto C. |
| Docosahexaenoic acid liposomes for targeting chronic inflammatory diseases and cancer : an in vitro assessment Journal Article (2016) | Alaarg, Amr Jordan, Nan Yeun Verhoef, Johan J. F. Metselaar, Josbert M. Storm, Gert Kok, Robbert J. (Corresponding author) |
| Polymeric Nanogels with Tailorable Degradation Behavior Journal Article (2016) | Chen, Yinan van Steenbergen, Mies J. Li, Dandan van de Dikkenberg, Joep B. Lammers, Twan van Nostrum, Cornelus F. Metselaar, Josbert M. Hennink, Wim E. (Corresponding author) |
| Multiple pathway assessment to predict anti-atherogenic efficacy of drugs targeting macrophages in atherosclerotic plaques Journal Article (2016) | Alaarg, Amr Zheng, Kang He van der Valk, Fleur M. da Silva, Acarilia Eduardo Versloot, Miranda Quarles van Ufford, Linda C. Schulte, Dominik M. Storm, Gert Metselaar, Josbert M. Stroes, Erik S. G. Hamers, Anouk A. J. |
| Nanoparticles for intravascular applications: physicochemical characterization and cytotoxicity testing Journal Article (2016) | Matuszak, Jasmin Baumgartner, Jens Zaloga, Jan Juenet, Maya da Silva, Acarília Eduardo Franke, Danielle Almer, Gunter Texier, Isabelle Faivre, Damien Metselaar, Josbert M. Navarro, Fabrice P. Chauvierre, Cédric Prassl, Ruth Dézsi, László Urbanics, Rudolf Alexiou, Christoph Mangge, Harald Szebeni, János Letourneur, Didier Cicha, Iwona (Corresponding author) |
| Liposomal corticosteroid treatment of experimental arthritis can be monitored non-invasively with radiolabeled anti-FAP antibodies Abstract, Contribution to a conference proceedings, Journal Article (2015) | van der Geest, Tessa Gerrits, D. Metselaar, Josbert M. Storm, G. Nayak, T. K. Freimoser-Grundschober, A. Klein, C. Walgreen, B. Helsen, M. M. Koenders, M. I. Laverman, P. Boerman, O. C. |
| A stable and remote 111In-labeling of DTPA-DSPE long-circulating liposomes Abstract, Contribution to a conference proceedings, Journal Article (2015) | van der Geest, Tessa Gerrits, D. Franssen, G. M. Metselaar, Josbert M. Storm, G. Laverman, P. Boerman, O. C. |
| Atherosclerotic Plaque Targeting Mechanism of Long-Circulating Nanoparticles Established by Multimodal Imaging Journal Article (2015) | Lobatto, Mark E. Calcagno, Claudia Millon, Antoine Senders, Max L. Fay, Francois Robson, Philip M. Ramachandran, Sarayu Binderup, Tina Paridaans, Maarten P. M. Sensarn, Steven Rogalla, Stephan Gordon, Ronald E. Cardoso, Luis Storm, Gert Metselaar, Josbert M. Contag, Christopher H. Stroes, Erik S. G. Fayad, Zahi A. Mulder, Willem J. M. (Corresponding author) |
| 111In-anti-F4/80-A3-1 antibody: a novel tracer to image macrophages Journal Article (2015) | Terry, Samantha Y. A. (Corresponding author) Boerman, Otto C. Gerrits, Danny Franssen, Gerben M. Metselaar, Josbert M. Lehmann, Steffi Oyen, Wim J. G. Gerdes, Christian A. Abiraj, Keelara |
| Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration Journal Article (2015) | van der Valk, Fleur M. van Wijk, Diederik F. Lobatto, Mark E. Verberne, Hein J. Storm, Gert Willems, Martine C. M. Legemate, Dink A. Nederveen, Aart J. Calcagno, Claudia Mani, Venkatesh Ramachandran, Sarayu Paridaans, Maarten P. M. Otten, Maarten J. Dallinga-Thie, Geesje M. Fayad, Zahi A. Nieuwdorp, Max Schulte, Dominik M. Metselaar, Josbert M. Mulder, Willem J. M. Stroes, Erik S. (Corresponding author) |
| Pharmaceutical development and preclinical evaluation of a GMP-grade anti-inflammatory nanotherapy Journal Article (2015) | Lobatto, Mark E. Calcagno, Claudia Otten, Maarten J. Millon, Antoine Ramachandran, Sarayu Paridaans, Maarten P. M. van der Valk, Fleur M. Storm, Gert Stroes, Erik S. G. Fayad, Zahi A. Mulder, Willem J. M. Metselaar, Josbert M. (Corresponding author) |
| Distribution of technetium-99m PEG-liposomes during oligofructose-induced laminitis development in horses Journal Article (2015) | Underwood, Claire (Corresponding author) Pollitt, Christopher C. Metselaar, Josbert M. Laverman, Peter van Bloois, Louis van den Hoven, Jolanda M. Storm, Gert van Eps, Andrew W. |
| Comparison of three remote radiolabelling methods for long-circulating liposomes Journal Article (2015) | van der Geest, Tessa (Corresponding author) Laverman, Peter Gerrits, Danny Franssen, Gerben M. Metselaar, Josbert M. Storm, Gert Boerman, Otto C. |
| [18]F FDG PET/CT imaging to monitor the therapeutic effect of liposome-encapsulated prednisolone in experimental rheumatoid arthritis Journal Article (2015) | van der Geest, Tessa (Corresponding author) Metselaar, Josbert M. Gerrits, Danny van Lent, Peter L. Storm, Gert Laverman, Peter Boerman, Otto C. |
| Liposomal delivery of dexamethasone attenuates prostate cancer bone metastatic tumor growth In Vivo Journal Article (2015) | Kroon, Jan (Corresponding author) Buijs, Jeroen T. van der Horst, Geertje Cheung, Henry van der Mark, Maaike van Bloois, Louis Rizzo, Larissa Y. Lammers, Twan Pelger, Rob C. Storm, Gert van der Pluijm, Gabri Metselaar, Josbert M. |
| Liposomal corticosteroids for the treatment of inflammatory disorders and cancer Contribution to a book, Journal Article (2014) | Ozbakir, B. Crielaard, B. J. Metselaar, Josbert M. Storm, G. Lammers, T. |
| Nanomedicines for Inflammatory Arthritis: Head-to-Head Comparison of Glucocorticoid-Containing Polymers, Micelles, and Liposomes Journal Article (2014) | Quan, Lingdong Zhang, Yijia Crielaard, Bart J. Dusad, Anand Lele, Subodh M. Rijcken, Cristianne J. F. Metselaar, Josbert M. Kostková, Hana Etrych, Tomas Ulbrich, Karel Kießling, Fabian Mikuls, Ted R. Hennink, Wim E. Storm, Gert Lammers, Twan (Corresponding author) Wang, Dong (Corresponding author) |