Person

Dr.

Josbert Maarten Metselaar

Lehrstuhl für Experimentelle Molekulare Bildgebung

Address

Building: CBMS

Room: 109

Forckenbeckstraße 55

52074 Aachen

Contact

WorkPhone
Phone: +49 241 80 85622
 

Josbert (Bart) (PharmD Utrecht University) obtained his PhD at in Pharmaceutics and Immunology in 2003 with a thesis novel targeted drug formulations for inflammation. After a postdoctorate in 2005 he founded the company Enceladus Pharmaceuticals BV. With this company he succeeded in conducting a series of preclinical and clinical studies on two different liposomal nanomedicine products. He could finance these studies by securing a series of research grants, two major company awards, various investments and pharmaceutical partnerships.

Since 2012 Bart has been working as a part-time associate professor of advanced drug delivery at the University of Twente. In 2015 he took a part-time group leader position at the RWTH Aachen. There he expanded his research into the development of liposomal and polymeric nanomedicines for the treatment of hematological cancers and solid tumors. He helped realize new funding for tumor-targeted drug delivery through research grants from DRG and BMBF.

 

Publications

Title Author(s)
? electron-stabilized polymeric micelles potentiate docetaxel therapy in advanced-stage gastrointestinal cancer
Journal Article (2021)
Liang, Chenghua
Bai, Xiangyang
Qi, Cuiling
Sun, Qingxue
Han, Xiaoyan
Lan, Tianyun
Zhang, Haibo
Zheng, Xiaoming
Liang, Rongpu
Jiao, Ju
Zheng, Zongheng
Fang, Jiafeng
Lei, Purun
Wang, Yan
Möckel, Diana
Metselaar, Josbert M.
Storm, Gert
Hennink, Wim E.
Kiessling, Fabian
Wei, Hongbo
Lammers, Twan
Shi, Yang
Wei, Bo
A review of the clinical applications of drug delivery systems for the treatment of ocular anterior segment inflammation
Journal Article (2020)
Wong, Chee Wai
Metselaar, Josbert M.
Storm, Gert
Wong, Tina T.
Systematic evaluation of design features enables efficient selection of ? electron-stabilized polymeric micelles
Journal Article (2020)
Sheybanifard, Maryam
Beztsinna, Nataliia
Bagheri, Mahsa
Buhl, Eva Miriam
Bresseleers, Jaleesa
Varela-Moreira, Aida
Shi, Yang
van Nostrum, Cornelus F.
van der Pluijm, Gabri
Storm, Gert
Hennink, Wim E.
Lammers, Twan
Metselaar, Josbert M.
Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance
Journal Article (2020)
Dadfar, Seyed Mohammadali
Camozzi, Denise
Darguzyte, Milita
Roemhild, Karolin
Varvarà, Paola
Metselaar, Josbert M.
Banala, Srinivas
Straub, Marcel
Güvener, Nihan
Engelmann, Ulrich
Slabu, Ioana
Buhl, Miriam
van Leusen, Jan
Kögerler, Paul
Hermanns-Sachweh, Benita
Schulz, Volkmar
Kiessling, Fabian
Lammers, Twan (Corresponding author)
Dexamethasone nanomedicines for COVID-19
Journal Article (2020)
Lammers, Twan
Sofias, Alexandros Marios
van der Meel, Roy
Schiffelers, Raymond
Storm, Gert
Tacke, Frank
Koschmieder, Steffen
Brümmendorf, Tim H.
Kiessling, Fabian
Metselaar, Josbert M.
Complete Tumor Regression by Liposomal Bortezomib in a Humanized Mouse Model of Multiple Myeloma
Journal Article (2020)
Deshantri, Anil K.
Fens, Marcel H. A. M.
Ruiter, Ruud W. J.
Metselaar, Josbert M.
Storm, Gert
Mandhane, Sanjay N.
Graat, Gerard H. M.
Lentjes, Eef G. W.
Yuan, Huipin
de Bruijn, Joost D.
Mutis, Tuna
Martens, Anton C. M.
Groen, Richard W. J.
Schiffelers, Raymond M.
A Randomized Trial of Liposomal Prednisolone (LIPMAT) to Enhance Radiocephalic Fistula Maturation: A Pilot Study
Journal Article (2020)
Voorzaat, Bram M.
van der Bogt, K. E. A.
Bezhaeva, Taisiya
van Schaik, Jan
Eefting, Daniel
van der Putten, Karien
van Nieuwenhuizen, Roos C.
Groeneveld, Johannes O.
Hoogeveen, Ellen K.
van der Meer, Irene M.
Statius van Eps, Randolph G.
Vogt, Liffert
Huisman, Laurens
Gabreëls, Bas A. Th F.
Boom, Henk
Verburgh, Cornelis A.
Boon, Diederik
Metselaar, Josbert M.
Weijmer, Marcel C.
Rotmans, Joris I.
A Doxorubicin-Glucuronide Prodrug Released from Nanogels Activated by High-Intensity Focused Ultrasound Liberated β-Glucuronidase
Contribution to a book, Journal Article (2020)
Besse, Helena C.
Chen, Yinan
Scheeren, Hans W.
Metselaar, Josbert M.
Lammers, Twan
Moonen, Chrit T. W.
Hennink, Wim E.
Deckers, Roel (Corresponding author)
Liposomal Delivery Improves the Efficacy of Prednisolone to Attenuate Renal Inflammation in a Mouse Model of Acute Renal Allograft Rejection
Journal Article (2020)
van Alem, Carla M. A.
Schmidbauer, Martina
Rong, Song
Derlin, Katja
Schmitz, Jessica
Bräsen, Jan H.
Thorenz, Anja
Chen, Rongjun
Ruben, Jurjen M.
Winter, Elizabeth M.
Schilperoort, Maaike
Kooijman, Sander
Lalai, Reshma A.
Metselaar, Josbert Maarten
Klemann, Christian
Meier, Martin
van Kooten, Cees
Gueler, Faikah
Rotmans, Joris I. (Corresponding author)
Challenges in nanomedicine clinical translation
Journal Article (2020)
Metselaar, Josbert M. (Corresponding author)
Lammers, Twan (Corresponding author)
Liposomal dexamethasone inhibits tumor growth in an advanced human-mouse hybrid model of multiple myeloma
Journal Article (2019)
Deshantri, Anil K.
Fens, Marcel H.
Ruiter, Ruud W. J.
Metselaar, Josbert M.
Storm, Gert
van Bloois, Louis
Varela-Moreira, Aida
Mandhane, Sanjay N.
Mutis, Tuna
Martens, Anton C. M.
Groen, Richard W. J.
Schiffelers, Raymond M. (Corresponding author)
Development and characterization of liposomal formulation of bortezomib
Journal Article (2019)
Deshantri, Anil K.
Metselaar, Josbert M.
Zagkou, Stavroula
Storm, Gert
Mandhane, Sanjay N.
Fens, Marcel H. A. M.
Schiffelers, Raymond M.
ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer
Journal Article (2019)
Kuninty, Praneeth R.
Bansal, Ruchi
De Geus, Susanna W. L.
Mardhian, Deby F.
Schnittert, Jonas
van Baarlen, Joop
Storm, Gert
Bijlsma, Maarten F.
van Laarhoven, Hanneke W.
Metselaar, Josbert M.
Kuppen, Peter J. K.
Vahrmeijer, Alexander L.
Östman, Arne
Sier, Cornelis F. M.
Prakash, Jai (Corresponding author)
Liposome-induced hypersensitivity reactions: Risk reduction by design of safe infusion protocols in pigs
Journal Article (2019)
Fülöp, Tamás
Kozma, Gergely T.
Vashegyi, Ildikó
Mészáros, Tamás
Rosivall, László
Urbanics, Rudolf
Storm, Gert
Metselaar, Josbert M.
Szebeni, János
From design to the clinic: practical guidelines for translating cardiovascular nanomedicine
Journal Article (2018)
Cicha, Iwona (Corresponding author)
Chauvierre, Cédric
Texier, Isabelle
Cabella, Claudia
Metselaar, Josbert M.
Szebeni, János
Dézsi, László
Alexiou, Christoph
Rouzet, François
Storm, Gert
Stroes, Erik
Bruce, Donald
MacRitchie, Neil
Maffia, Pasquale
Letourneur, Didier
Imaging fibroblast activation protein to monitor therapeutic effects of neutralizing interleukin-22 in collagen-induced arthritis
Journal Article (2018)
van der Geest, Tessa
Roeleveld, Debbie M.
Walgreen, Birgitte
Helsen, Monique M.
Nayak, Tapan K.
Klein, Christian
Hegen, Martin
Storm, Gert
Metselaar, Josbert M.
van den Berg, Wim B.
van der Kraan, Peter M.
Laverman, Peter
Boerman, Otto C.
Koenders, Marije I. (Corresponding author)
Effect of Formulation and Processing Parameters on the Size of mPEG-b-p(HPMA-Bz) Polymeric Micelles
Journal Article (2018)
Bagheri, Mahsa
Bresseleers, Jaleesa
Varela-Moreira, Aida
Sandre, Olivier
Meeuwissen, Silvie A.
Schiffelers, Raymond M.
Metselaar, Josbert M.
van Nostrum, Cornelus F.
van Hest, Jan C. M.
Hennink, Wim E. (Corresponding author)
Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis
Journal Article (2018)
Wong, Chee Wai
Czarny, Bertrand
Metselaar, Josbert M.
Ho, Candice
Ng, Si Rui
Barathi, Amutha Veluchamy
Storm, Gert
Wong, Tina T.
Local delivery of liposomal prednisolone leads to an anti-inflammatory profile in renal ischaemia–reperfusion injury in the rat
Journal Article (2018)
van Alem, Carla M. A.
Boonstra, Mark
Prins, Jurriën
Bezhaeva, Taisiya
van Essen, Mieke F.
Ruben, Jurjen M.
Vahrmeijer, Alexander L.
van der Veer, Eric P.
De Fijter, Johan W.
Reinders, Marlies E.
Meijer, Onno
Metselaar, Josbert M.
van Kooten, Cees
Rotmans, Joris I. (Corresponding author)
Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization
Journal Article (2018)
Hua, Susan (Corresponding author)
de Matos, Maria B. C.
Metselaar, Josbert M.
Storm, Gert
Comparative analysis of nanosystems’ effects on human endothelial and monocytic cell functions
Journal Article (2018)
Matuszak, Jasmin
Dörfler, Philipp
Lyer, Stefan
Unterweger, Harald
Juenet, Maya
Chauvierre, Cédric
Alaarg, Amr
Franke, Danielle
Almer, Gunter
Texier, Isabelle
Metselaar, Josbert M.
Prassl, Ruth
Alexiou, Christoph
Mangge, Harald
Letourneur, Didier
Cicha, Iwona (Corresponding author)
In Vitro Evaluation of Anti-Aggregation and Degradation Behavior of PEGylated Polymeric Nanogels under In Vivo Like Conditions
Contribution to a book, Journal Article (2017)
Chen, Yinan
Dakwar, George R.
Braeckmans, Kevin
Lammers, Twan
Hennink, Wim E. (Corresponding author)
Metselaar, Josbert M. (Corresponding author)
Applying nanomedicine in maladaptive inflammation and angiogenesis☆
Contribution to a book, Journal Article (2017)
Alaarg, Amr
Pérez-Medina, Carlos
Metselaar, Josbert M.
Nahrendorf, Matthias
Fayad, Zahi A.
Storm, Gert
Mulder, Willem J. M. (Corresponding author)
Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction
Journal Article (2017)
Allijn, Iris E.
Czarny, Bertrand M. S.
Wang, Xiaoyuan
Chong, Suet Yen
Weiler, Marek
da Silva, Acarilia Eduardo
Metselaar, Josbert M.
Lam, Carolyn Su Ping
Pastorin, Giorgia
de Kleijn, Dominique P. V.
Storm, Gert
Wang, Jiong-Wei
Schiffelers, Raymond M. (Corresponding author)
In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow
Journal Article (2017)
van der Meer, Laurens T.
Terry, Samantha Y. A.
van Ingen Schenau, Dorette S.
Andree, Kiki C.
Franssen, Gerben M.
Roeleveld, Debbie M.
Metselaar, Josbert M.
Reinheckel, Thomas
Hoogerbrugge, Peter M.
Boerman, Otto C.
van Leeuwen, Frank N.
A systematic comparison of clinically viable nanomedicines targeting HMG-CoA reductase in inflammatory atherosclerosis
Journal Article (2017)
Alaarg, Amr
Senders, Max L.
Varela-Moreira, Aida
Pérez-Medina, Carlos
Zhao, Yiming
Tang, Jun
Fay, Francois
Reiner, Thomas
Fayad, Zahi A.
Hennink, Wim E.
Metselaar, Josbert M.
Mulder, Willem J. M. (Corresponding author)
Storm, Gert (Corresponding author)
Overcoming multidrug resistance using folate receptor-targeted and pH-responsive polymeric nanogels containing covalently entrapped doxorubicin
Journal Article (2017)
Chen, Y. (Corresponding author)
Tezcan, O.
Li, D.
Beztsinna, N.
Lou, B.
Etrych, T.
Ulbrich, K.
Metselaar, J. M.
Lammers, T.
Hennink, W. E. (Corresponding author)
Liposomal Treatment of Experimental Arthritis Can Be Monitored Noninvasively with a Radiolabeled Anti-Fibroblast Activation Protein Antibody
Journal Article (2017)
van der Geest, Tessa (Corresponding author)
Laverman, Peter
Gerrits, Danny
Walgreen, Birgitte
Helsen, Monique M.
Klein, Christian
Nayak, Tapan K.
Storm, Gert
Metselaar, Josbert M.
Koenders, Marije I.
Boerman, Otto C.
Glucocorticoid receptor antagonism reverts docetaxel resistance in human prostate cancer
Journal Article (2015)
Kroon, Jan
Puhr, Martin
Buijs, Jeroen T.
van der Horst, Geertje
Hemmer, Daniëlle M.
Marijt, Koen A.
Hwang, Ming S.
Masood, Motasim
Grimm, Stefan
Storm, Gert
Metselaar, Josbert M.
Meijer, Onno C.
Culig, Zoran
van der Pluijm, Gabri (Corresponding author)
Radionuclide imaging of liposomal drug delivery
Journal Article (2016)
van der Geest, Tessa (Corresponding author)
Laverman, Peter
Metselaar, Josbert M.
Storm, Gert
Boerman, Otto C.
Docosahexaenoic acid liposomes for targeting chronic inflammatory diseases and cancer : an in vitro assessment
Journal Article (2016)
Alaarg, Amr
Jordan, Nan Yeun
Verhoef, Johan J. F.
Metselaar, Josbert M.
Storm, Gert
Kok, Robbert J. (Corresponding author)
Polymeric Nanogels with Tailorable Degradation Behavior
Journal Article (2016)
Chen, Yinan
van Steenbergen, Mies J.
Li, Dandan
van de Dikkenberg, Joep B.
Lammers, Twan
van Nostrum, Cornelus F.
Metselaar, Josbert M.
Hennink, Wim E. (Corresponding author)
Multiple pathway assessment to predict anti-atherogenic efficacy of drugs targeting macrophages in atherosclerotic plaques
Journal Article (2016)
Alaarg, Amr
Zheng, Kang He
van der Valk, Fleur M.
da Silva, Acarilia Eduardo
Versloot, Miranda
Quarles van Ufford, Linda C.
Schulte, Dominik M.
Storm, Gert
Metselaar, Josbert M.
Stroes, Erik S. G.
Hamers, Anouk A. J.
Nanoparticles for intravascular applications: physicochemical characterization and cytotoxicity testing
Journal Article (2016)
Matuszak, Jasmin
Baumgartner, Jens
Zaloga, Jan
Juenet, Maya
da Silva, Acarília Eduardo
Franke, Danielle
Almer, Gunter
Texier, Isabelle
Faivre, Damien
Metselaar, Josbert M.
Navarro, Fabrice P.
Chauvierre, Cédric
Prassl, Ruth
Dézsi, László
Urbanics, Rudolf
Alexiou, Christoph
Mangge, Harald
Szebeni, János
Letourneur, Didier
Cicha, Iwona (Corresponding author)
Liposomal corticosteroid treatment of experimental arthritis can be monitored non-invasively with radiolabeled anti-FAP antibodies
Abstract, Contribution to a conference proceedings, Journal Article (2015)
van der Geest, Tessa
Gerrits, D.
Metselaar, Josbert M.
Storm, G.
Nayak, T. K.
Freimoser-Grundschober, A.
Klein, C.
Walgreen, B.
Helsen, M. M.
Koenders, M. I.
Laverman, P.
Boerman, O. C.
A stable and remote 111In-labeling of DTPA-DSPE long-circulating liposomes
Abstract, Contribution to a conference proceedings, Journal Article (2015)
van der Geest, Tessa
Gerrits, D.
Franssen, G. M.
Metselaar, Josbert M.
Storm, G.
Laverman, P.
Boerman, O. C.
Atherosclerotic Plaque Targeting Mechanism of Long-Circulating Nanoparticles Established by Multimodal Imaging
Journal Article (2015)
Lobatto, Mark E.
Calcagno, Claudia
Millon, Antoine
Senders, Max L.
Fay, Francois
Robson, Philip M.
Ramachandran, Sarayu
Binderup, Tina
Paridaans, Maarten P. M.
Sensarn, Steven
Rogalla, Stephan
Gordon, Ronald E.
Cardoso, Luis
Storm, Gert
Metselaar, Josbert M.
Contag, Christopher H.
Stroes, Erik S. G.
Fayad, Zahi A.
Mulder, Willem J. M. (Corresponding author)
111In-anti-F4/80-A3-1 antibody: a novel tracer to image macrophages
Journal Article (2015)
Terry, Samantha Y. A. (Corresponding author)
Boerman, Otto C.
Gerrits, Danny
Franssen, Gerben M.
Metselaar, Josbert M.
Lehmann, Steffi
Oyen, Wim J. G.
Gerdes, Christian A.
Abiraj, Keelara
Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration
Journal Article (2015)
van der Valk, Fleur M.
van Wijk, Diederik F.
Lobatto, Mark E.
Verberne, Hein J.
Storm, Gert
Willems, Martine C. M.
Legemate, Dink A.
Nederveen, Aart J.
Calcagno, Claudia
Mani, Venkatesh
Ramachandran, Sarayu
Paridaans, Maarten P. M.
Otten, Maarten J.
Dallinga-Thie, Geesje M.
Fayad, Zahi A.
Nieuwdorp, Max
Schulte, Dominik M.
Metselaar, Josbert M.
Mulder, Willem J. M.
Stroes, Erik S. (Corresponding author)
Pharmaceutical development and preclinical evaluation of a GMP-grade anti-inflammatory nanotherapy
Journal Article (2015)
Lobatto, Mark E.
Calcagno, Claudia
Otten, Maarten J.
Millon, Antoine
Ramachandran, Sarayu
Paridaans, Maarten P. M.
van der Valk, Fleur M.
Storm, Gert
Stroes, Erik S. G.
Fayad, Zahi A.
Mulder, Willem J. M.
Metselaar, Josbert M. (Corresponding author)
Distribution of technetium-99m PEG-liposomes during oligofructose-induced laminitis development in horses
Journal Article (2015)
Underwood, Claire (Corresponding author)
Pollitt, Christopher C.
Metselaar, Josbert M.
Laverman, Peter
van Bloois, Louis
van den Hoven, Jolanda M.
Storm, Gert
van Eps, Andrew W.
Comparison of three remote radiolabelling methods for long-circulating liposomes
Journal Article (2015)
van der Geest, Tessa (Corresponding author)
Laverman, Peter
Gerrits, Danny
Franssen, Gerben M.
Metselaar, Josbert M.
Storm, Gert
Boerman, Otto C.
[18]F FDG PET/CT imaging to monitor the therapeutic effect of liposome-encapsulated prednisolone in experimental rheumatoid arthritis
Journal Article (2015)
van der Geest, Tessa (Corresponding author)
Metselaar, Josbert M.
Gerrits, Danny
van Lent, Peter L.
Storm, Gert
Laverman, Peter
Boerman, Otto C.
Liposomal delivery of dexamethasone attenuates prostate cancer bone metastatic tumor growth In Vivo
Journal Article (2015)
Kroon, Jan (Corresponding author)
Buijs, Jeroen T.
van der Horst, Geertje
Cheung, Henry
van der Mark, Maaike
van Bloois, Louis
Rizzo, Larissa Y.
Lammers, Twan
Pelger, Rob C.
Storm, Gert
van der Pluijm, Gabri
Metselaar, Josbert M.
Liposomal corticosteroids for the treatment of inflammatory disorders and cancer
Contribution to a book, Journal Article (2014)
Ozbakir, B.
Crielaard, B. J.
Metselaar, Josbert M.
Storm, G.
Lammers, T.
Nanomedicines for Inflammatory Arthritis: Head-to-Head Comparison of Glucocorticoid-Containing Polymers, Micelles, and Liposomes
Journal Article (2014)
Quan, Lingdong
Zhang, Yijia
Crielaard, Bart J.
Dusad, Anand
Lele, Subodh M.
Rijcken, Cristianne J. F.
Metselaar, Josbert M.
Kostková, Hana
Etrych, Tomas
Ulbrich, Karel
Kießling, Fabian
Mikuls, Ted R.
Hennink, Wim E.
Storm, Gert
Lammers, Twan (Corresponding author)
Wang, Dong (Corresponding author)